Blood pressure measurement in SPRINT (Systolic Blood Pressure Intervention Trial)

Karen Johnson, Paul K. Whelton, William Cushman, Jeffrey A. Cutler, Gregory W. Evans, Joni K. Snyder, Walter T. Ambrosius, Srinivasan Beddhu, Alfred K. Cheung, Lawrence J. Fine, Cora E. Lewis, Mahboob Rahman, David M. Reboussin, Michael V. Rocco, Suzanne Oparil, Jackson T. Wright

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Recent publications have stated that the blood pressure (BP) measurement technique used in SPRINT (Systolic Blood Pressure Intervention Trial) was unattended. However, the SPRINT protocol does not address the issue of attendance. A survey was conducted immediately after SPRINT closeout visits were completed to inquire whether BP measurements were usually attended or unattended by staff. There were 4082 participants at 38 sites that measured BP after leaving the participant alone the entire time (always alone), 2247 at 25 sites that had personnel in the room the entire time (never alone), 1746 at 19 sites that left the participant alone only during the rest period (alone for rest), and 570 at 6 sites that left the participant alone only during the BP readings (alone for BP measurement). Similar systolic and diastolic BPs within randomized groups were noted during follow-up at the majority of visits in all 4 measurement categories. In the always alone and never alone categories, the intensive group had a similarly reduced risk for the primary outcome compared with the standard group (hazard ratio, 0.62; 95% confidence interval, 0.51-0.76 and hazard ratio, 0.64; 95% confidence interval, 0.46-0.91, respectively; pairwise interaction P value, 0.88); risk was not significantly reduced for the intensive group in the smaller alone-for-rest and the alone-for-BP-measurement categories. Similar BP levels and cardiovascular disease risk reduction were observed in the intensive group in SPRINT participants whether the measurement technique used was primarily attended or unattended.

Original languageEnglish (US)
Pages (from-to)848-857
Number of pages10
JournalHypertension
Volume71
Issue number5
DOIs
StatePublished - May 1 2018

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Blood Pressure
Confidence Intervals
Risk Reduction Behavior
Clinical Protocols
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Cardiovascular Diseases

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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Blood pressure measurement in SPRINT (Systolic Blood Pressure Intervention Trial). / Johnson, Karen; Whelton, Paul K.; Cushman, William; Cutler, Jeffrey A.; Evans, Gregory W.; Snyder, Joni K.; Ambrosius, Walter T.; Beddhu, Srinivasan; Cheung, Alfred K.; Fine, Lawrence J.; Lewis, Cora E.; Rahman, Mahboob; Reboussin, David M.; Rocco, Michael V.; Oparil, Suzanne; Wright, Jackson T.

In: Hypertension, Vol. 71, No. 5, 01.05.2018, p. 848-857.

Research output: Contribution to journalArticle

Johnson, K, Whelton, PK, Cushman, W, Cutler, JA, Evans, GW, Snyder, JK, Ambrosius, WT, Beddhu, S, Cheung, AK, Fine, LJ, Lewis, CE, Rahman, M, Reboussin, DM, Rocco, MV, Oparil, S & Wright, JT 2018, 'Blood pressure measurement in SPRINT (Systolic Blood Pressure Intervention Trial)', Hypertension, vol. 71, no. 5, pp. 848-857. https://doi.org/10.1161/HYPERTENSIONAHA.117.10479
Johnson, Karen ; Whelton, Paul K. ; Cushman, William ; Cutler, Jeffrey A. ; Evans, Gregory W. ; Snyder, Joni K. ; Ambrosius, Walter T. ; Beddhu, Srinivasan ; Cheung, Alfred K. ; Fine, Lawrence J. ; Lewis, Cora E. ; Rahman, Mahboob ; Reboussin, David M. ; Rocco, Michael V. ; Oparil, Suzanne ; Wright, Jackson T. / Blood pressure measurement in SPRINT (Systolic Blood Pressure Intervention Trial). In: Hypertension. 2018 ; Vol. 71, No. 5. pp. 848-857.
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