Blood pressure responses to dietary sodium and potassium interventions and the cold pressor test

The gensalt replication study in rural North China

Qi Zhao, Dongfeng Gu, Jichun Chen, Jianxin Li, Jie Cao, Fanghong Lu, Dongshuang Guo, Renping Wang, Jinjin Shen, Jing Chen, Chung Shiuan Chen, Katherine T. Mills, Karen Schwander, Dabeeru C. Rao, Jiang He

Research output: Contribution to journalArticle

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Abstract

background In the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) study, we observed that blood pressure (BP) responses to dietary sodium and potassium interventions and the cold pressor test (CPT) varied greatly among individuals. We conducted a replication study to confirm our previous findings among 695 study participants. methods The dietary intervention included a 7-day low sodium (51.3 mmol/day), a 7-day high sodium (307.8 mmol/day), and a 7-day high sodium with potassium supplementation (307.8 mmol sodium and 60 mmol potassium/ day). BP measurements were obtained during the baseline and each intervention phase. During the CPT, BP was measured before and at 0, 1, 2, and 4 minutes after the participants immersed their right hand in ice water for 1 minute. results Systolic and diastolic BP responses (mean ± SD (range), mm Hg) were 8.1 ± 8.4 (-39.1 to 18.2) and -3.5 ± 5.1 (-25.1 to 11.1) to low sodium, 9.1 ± 8.4 (-13.3 to 33.1) and 4.0 ± 5.4 (-16.0 to 20.7) to high sodium, and -4.6 ± 5.8 (-31.8 to 11.6) and -1.9 ± 4.3 (-16.9 to 14.2) to potassium supplementation, respectively (all P < 0.0001 for comparison with each former phase). The mean maximum systolic and diastolic BP responses to the CPT were 16.5 ± 10.5 (-15.3 to 63.3) and 7.6 ± 6.1 (-8.7 to 39.3), respectively (all P < 0.0001). conclusions Our study indicates that there are large variations in BP responses to dietary sodium and potassium interventions and to the CPT among individuals.

Original languageEnglish (US)
Pages (from-to)72-80
Number of pages9
JournalAmerican journal of hypertension
Volume27
Issue number1
DOIs
StatePublished - Jan 1 2014

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Dietary Potassium
Dietary Sodium
China
Blood Pressure
Sodium
Potassium
Molecular Epidemiology
Ice
Hand
Salts

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Blood pressure responses to dietary sodium and potassium interventions and the cold pressor test : The gensalt replication study in rural North China. / Zhao, Qi; Gu, Dongfeng; Chen, Jichun; Li, Jianxin; Cao, Jie; Lu, Fanghong; Guo, Dongshuang; Wang, Renping; Shen, Jinjin; Chen, Jing; Chen, Chung Shiuan; Mills, Katherine T.; Schwander, Karen; Rao, Dabeeru C.; He, Jiang.

In: American journal of hypertension, Vol. 27, No. 1, 01.01.2014, p. 72-80.

Research output: Contribution to journalArticle

Zhao, Q, Gu, D, Chen, J, Li, J, Cao, J, Lu, F, Guo, D, Wang, R, Shen, J, Chen, J, Chen, CS, Mills, KT, Schwander, K, Rao, DC & He, J 2014, 'Blood pressure responses to dietary sodium and potassium interventions and the cold pressor test: The gensalt replication study in rural North China', American journal of hypertension, vol. 27, no. 1, pp. 72-80. https://doi.org/10.1093/ajh/hpt163
Zhao, Qi ; Gu, Dongfeng ; Chen, Jichun ; Li, Jianxin ; Cao, Jie ; Lu, Fanghong ; Guo, Dongshuang ; Wang, Renping ; Shen, Jinjin ; Chen, Jing ; Chen, Chung Shiuan ; Mills, Katherine T. ; Schwander, Karen ; Rao, Dabeeru C. ; He, Jiang. / Blood pressure responses to dietary sodium and potassium interventions and the cold pressor test : The gensalt replication study in rural North China. In: American journal of hypertension. 2014 ; Vol. 27, No. 1. pp. 72-80.
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abstract = "background In the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) study, we observed that blood pressure (BP) responses to dietary sodium and potassium interventions and the cold pressor test (CPT) varied greatly among individuals. We conducted a replication study to confirm our previous findings among 695 study participants. methods The dietary intervention included a 7-day low sodium (51.3 mmol/day), a 7-day high sodium (307.8 mmol/day), and a 7-day high sodium with potassium supplementation (307.8 mmol sodium and 60 mmol potassium/ day). BP measurements were obtained during the baseline and each intervention phase. During the CPT, BP was measured before and at 0, 1, 2, and 4 minutes after the participants immersed their right hand in ice water for 1 minute. results Systolic and diastolic BP responses (mean ± SD (range), mm Hg) were 8.1 ± 8.4 (-39.1 to 18.2) and -3.5 ± 5.1 (-25.1 to 11.1) to low sodium, 9.1 ± 8.4 (-13.3 to 33.1) and 4.0 ± 5.4 (-16.0 to 20.7) to high sodium, and -4.6 ± 5.8 (-31.8 to 11.6) and -1.9 ± 4.3 (-16.9 to 14.2) to potassium supplementation, respectively (all P < 0.0001 for comparison with each former phase). The mean maximum systolic and diastolic BP responses to the CPT were 16.5 ± 10.5 (-15.3 to 63.3) and 7.6 ± 6.1 (-8.7 to 39.3), respectively (all P < 0.0001). conclusions Our study indicates that there are large variations in BP responses to dietary sodium and potassium interventions and to the CPT among individuals.",
author = "Qi Zhao and Dongfeng Gu and Jichun Chen and Jianxin Li and Jie Cao and Fanghong Lu and Dongshuang Guo and Renping Wang and Jinjin Shen and Jing Chen and Chen, {Chung Shiuan} and Mills, {Katherine T.} and Karen Schwander and Rao, {Dabeeru C.} and Jiang He",
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T1 - Blood pressure responses to dietary sodium and potassium interventions and the cold pressor test

T2 - The gensalt replication study in rural North China

AU - Zhao, Qi

AU - Gu, Dongfeng

AU - Chen, Jichun

AU - Li, Jianxin

AU - Cao, Jie

AU - Lu, Fanghong

AU - Guo, Dongshuang

AU - Wang, Renping

AU - Shen, Jinjin

AU - Chen, Jing

AU - Chen, Chung Shiuan

AU - Mills, Katherine T.

AU - Schwander, Karen

AU - Rao, Dabeeru C.

AU - He, Jiang

PY - 2014/1/1

Y1 - 2014/1/1

N2 - background In the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) study, we observed that blood pressure (BP) responses to dietary sodium and potassium interventions and the cold pressor test (CPT) varied greatly among individuals. We conducted a replication study to confirm our previous findings among 695 study participants. methods The dietary intervention included a 7-day low sodium (51.3 mmol/day), a 7-day high sodium (307.8 mmol/day), and a 7-day high sodium with potassium supplementation (307.8 mmol sodium and 60 mmol potassium/ day). BP measurements were obtained during the baseline and each intervention phase. During the CPT, BP was measured before and at 0, 1, 2, and 4 minutes after the participants immersed their right hand in ice water for 1 minute. results Systolic and diastolic BP responses (mean ± SD (range), mm Hg) were 8.1 ± 8.4 (-39.1 to 18.2) and -3.5 ± 5.1 (-25.1 to 11.1) to low sodium, 9.1 ± 8.4 (-13.3 to 33.1) and 4.0 ± 5.4 (-16.0 to 20.7) to high sodium, and -4.6 ± 5.8 (-31.8 to 11.6) and -1.9 ± 4.3 (-16.9 to 14.2) to potassium supplementation, respectively (all P < 0.0001 for comparison with each former phase). The mean maximum systolic and diastolic BP responses to the CPT were 16.5 ± 10.5 (-15.3 to 63.3) and 7.6 ± 6.1 (-8.7 to 39.3), respectively (all P < 0.0001). conclusions Our study indicates that there are large variations in BP responses to dietary sodium and potassium interventions and to the CPT among individuals.

AB - background In the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) study, we observed that blood pressure (BP) responses to dietary sodium and potassium interventions and the cold pressor test (CPT) varied greatly among individuals. We conducted a replication study to confirm our previous findings among 695 study participants. methods The dietary intervention included a 7-day low sodium (51.3 mmol/day), a 7-day high sodium (307.8 mmol/day), and a 7-day high sodium with potassium supplementation (307.8 mmol sodium and 60 mmol potassium/ day). BP measurements were obtained during the baseline and each intervention phase. During the CPT, BP was measured before and at 0, 1, 2, and 4 minutes after the participants immersed their right hand in ice water for 1 minute. results Systolic and diastolic BP responses (mean ± SD (range), mm Hg) were 8.1 ± 8.4 (-39.1 to 18.2) and -3.5 ± 5.1 (-25.1 to 11.1) to low sodium, 9.1 ± 8.4 (-13.3 to 33.1) and 4.0 ± 5.4 (-16.0 to 20.7) to high sodium, and -4.6 ± 5.8 (-31.8 to 11.6) and -1.9 ± 4.3 (-16.9 to 14.2) to potassium supplementation, respectively (all P < 0.0001 for comparison with each former phase). The mean maximum systolic and diastolic BP responses to the CPT were 16.5 ± 10.5 (-15.3 to 63.3) and 7.6 ± 6.1 (-8.7 to 39.3), respectively (all P < 0.0001). conclusions Our study indicates that there are large variations in BP responses to dietary sodium and potassium interventions and to the CPT among individuals.

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