Body mass index and mortality in kidney transplant recipients: A systematic review and meta-analysis

Seyed Foad Ahmadi, Golara Zahmatkesh, Elani Streja, Miklos Z. Molnar, Connie M. Rhee, Csaba Kovesdy, Daniel L. Gillen, Shah Steiner, Kamyar Kalantar-Zadeh

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

Background: A higher body mass index (BMI) seems to be linked to survival advantage in maintenance hemodialysis patients. However, it is uncertain if this 'obesity survival paradox' is also observed in kidney transplant recipients. Hence, we systematically reviewed the literature on the impact of pre-transplantation BMI on all-cause mortality in this population. Methods: We searched MEDLINE, EMBASE, Web of Science, CINAHL, and Cochrane CENTRAL for relevant studies up to July 2013. Two investigators independently selected the studies using predefined criteria, abstracted the data from the included studies, and independently assessed each study's quality using the Newcastle-Ottawa Quality Assessment Scale. In addition to the qualitative synthesis, we quantitatively pooled the results of the studies with clinical, methodological, and statistical homogeneity. Results: We screened 7,123 records, from which we included 11 studies (with a total of 305,392 participants) in this systematic review and 4 studies in the meta-analyses. In the only study that included children, obesity was linked to higher mortality in children of 6-12 years old. For adults, our meta-analyses indicated that compared to normal BMI, underweight [Hazard Ratio (HR): 1.09; 95% Confidence Interval (CI): 1.02-1.20], overweight (HR: 1.07; 95% CI: 1.04-1.12), and obese (HR: 1.20; 95% CI: 1.14-1.23) levels of BMI were associated with higher mortality. Conclusion: The presence of the obesity survival paradox is unlikely in kidney transplant recipients since both extremes of pre-transplantation BMI are linked to higher mortality in this population.

Original languageEnglish (US)
Pages (from-to)315-324
Number of pages10
JournalAmerican Journal of Nephrology
Volume40
Issue number4
DOIs
StatePublished - May 22 2014

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Meta-Analysis
Body Mass Index
Kidney
Mortality
Confidence Intervals
Survival
Obesity
Transplantation
Child Mortality
Thinness
Pediatric Obesity
MEDLINE
Population
Renal Dialysis
Maintenance
Research Personnel
Transplant Recipients

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Ahmadi, S. F., Zahmatkesh, G., Streja, E., Molnar, M. Z., Rhee, C. M., Kovesdy, C., ... Kalantar-Zadeh, K. (2014). Body mass index and mortality in kidney transplant recipients: A systematic review and meta-analysis. American Journal of Nephrology, 40(4), 315-324. https://doi.org/10.1159/000367812

Body mass index and mortality in kidney transplant recipients : A systematic review and meta-analysis. / Ahmadi, Seyed Foad; Zahmatkesh, Golara; Streja, Elani; Molnar, Miklos Z.; Rhee, Connie M.; Kovesdy, Csaba; Gillen, Daniel L.; Steiner, Shah; Kalantar-Zadeh, Kamyar.

In: American Journal of Nephrology, Vol. 40, No. 4, 22.05.2014, p. 315-324.

Research output: Contribution to journalReview article

Ahmadi, SF, Zahmatkesh, G, Streja, E, Molnar, MZ, Rhee, CM, Kovesdy, C, Gillen, DL, Steiner, S & Kalantar-Zadeh, K 2014, 'Body mass index and mortality in kidney transplant recipients: A systematic review and meta-analysis', American Journal of Nephrology, vol. 40, no. 4, pp. 315-324. https://doi.org/10.1159/000367812
Ahmadi, Seyed Foad ; Zahmatkesh, Golara ; Streja, Elani ; Molnar, Miklos Z. ; Rhee, Connie M. ; Kovesdy, Csaba ; Gillen, Daniel L. ; Steiner, Shah ; Kalantar-Zadeh, Kamyar. / Body mass index and mortality in kidney transplant recipients : A systematic review and meta-analysis. In: American Journal of Nephrology. 2014 ; Vol. 40, No. 4. pp. 315-324.
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abstract = "Background: A higher body mass index (BMI) seems to be linked to survival advantage in maintenance hemodialysis patients. However, it is uncertain if this 'obesity survival paradox' is also observed in kidney transplant recipients. Hence, we systematically reviewed the literature on the impact of pre-transplantation BMI on all-cause mortality in this population. Methods: We searched MEDLINE, EMBASE, Web of Science, CINAHL, and Cochrane CENTRAL for relevant studies up to July 2013. Two investigators independently selected the studies using predefined criteria, abstracted the data from the included studies, and independently assessed each study's quality using the Newcastle-Ottawa Quality Assessment Scale. In addition to the qualitative synthesis, we quantitatively pooled the results of the studies with clinical, methodological, and statistical homogeneity. Results: We screened 7,123 records, from which we included 11 studies (with a total of 305,392 participants) in this systematic review and 4 studies in the meta-analyses. In the only study that included children, obesity was linked to higher mortality in children of 6-12 years old. For adults, our meta-analyses indicated that compared to normal BMI, underweight [Hazard Ratio (HR): 1.09; 95{\%} Confidence Interval (CI): 1.02-1.20], overweight (HR: 1.07; 95{\%} CI: 1.04-1.12), and obese (HR: 1.20; 95{\%} CI: 1.14-1.23) levels of BMI were associated with higher mortality. Conclusion: The presence of the obesity survival paradox is unlikely in kidney transplant recipients since both extremes of pre-transplantation BMI are linked to higher mortality in this population.",
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T2 - A systematic review and meta-analysis

AU - Ahmadi, Seyed Foad

AU - Zahmatkesh, Golara

AU - Streja, Elani

AU - Molnar, Miklos Z.

AU - Rhee, Connie M.

AU - Kovesdy, Csaba

AU - Gillen, Daniel L.

AU - Steiner, Shah

AU - Kalantar-Zadeh, Kamyar

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N2 - Background: A higher body mass index (BMI) seems to be linked to survival advantage in maintenance hemodialysis patients. However, it is uncertain if this 'obesity survival paradox' is also observed in kidney transplant recipients. Hence, we systematically reviewed the literature on the impact of pre-transplantation BMI on all-cause mortality in this population. Methods: We searched MEDLINE, EMBASE, Web of Science, CINAHL, and Cochrane CENTRAL for relevant studies up to July 2013. Two investigators independently selected the studies using predefined criteria, abstracted the data from the included studies, and independently assessed each study's quality using the Newcastle-Ottawa Quality Assessment Scale. In addition to the qualitative synthesis, we quantitatively pooled the results of the studies with clinical, methodological, and statistical homogeneity. Results: We screened 7,123 records, from which we included 11 studies (with a total of 305,392 participants) in this systematic review and 4 studies in the meta-analyses. In the only study that included children, obesity was linked to higher mortality in children of 6-12 years old. For adults, our meta-analyses indicated that compared to normal BMI, underweight [Hazard Ratio (HR): 1.09; 95% Confidence Interval (CI): 1.02-1.20], overweight (HR: 1.07; 95% CI: 1.04-1.12), and obese (HR: 1.20; 95% CI: 1.14-1.23) levels of BMI were associated with higher mortality. Conclusion: The presence of the obesity survival paradox is unlikely in kidney transplant recipients since both extremes of pre-transplantation BMI are linked to higher mortality in this population.

AB - Background: A higher body mass index (BMI) seems to be linked to survival advantage in maintenance hemodialysis patients. However, it is uncertain if this 'obesity survival paradox' is also observed in kidney transplant recipients. Hence, we systematically reviewed the literature on the impact of pre-transplantation BMI on all-cause mortality in this population. Methods: We searched MEDLINE, EMBASE, Web of Science, CINAHL, and Cochrane CENTRAL for relevant studies up to July 2013. Two investigators independently selected the studies using predefined criteria, abstracted the data from the included studies, and independently assessed each study's quality using the Newcastle-Ottawa Quality Assessment Scale. In addition to the qualitative synthesis, we quantitatively pooled the results of the studies with clinical, methodological, and statistical homogeneity. Results: We screened 7,123 records, from which we included 11 studies (with a total of 305,392 participants) in this systematic review and 4 studies in the meta-analyses. In the only study that included children, obesity was linked to higher mortality in children of 6-12 years old. For adults, our meta-analyses indicated that compared to normal BMI, underweight [Hazard Ratio (HR): 1.09; 95% Confidence Interval (CI): 1.02-1.20], overweight (HR: 1.07; 95% CI: 1.04-1.12), and obese (HR: 1.20; 95% CI: 1.14-1.23) levels of BMI were associated with higher mortality. Conclusion: The presence of the obesity survival paradox is unlikely in kidney transplant recipients since both extremes of pre-transplantation BMI are linked to higher mortality in this population.

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