Body mass index, waist circumference and mortality in kidney transplant recipients

Csaba Kovesdy, M. E. Czira, A. Rudas, A. Ujszaszi, L. Rosivall, M. Novak, K. Kalantar-Zadeh, M. Z. Molnar, I. Mucsi

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Higher body mass index (BMI) appears paradoxically associated with better outcomes in patients with chronic kidney disease. Whereas higher BMI reflects both increased visceral and subcutaneous fat and/or muscle mass, a combined assessment of BMI and waist circumference may enable differentiation of visceral adiposity from muscle and/or nonvisceral fat mass. We examined the association of BMI and waist circumference with all-cause mortality in a prospective cohort of 993 kidney transplant recipients. Associations were examined in Cox models with adjustment for demographic and comorbid conditions and for inflammatory markers. Unadjusted death hazard ratios (95%CI) associated with one standard deviation higher BMI and waist circumference were 0.94 (0.78, 1.13), p = 0.5 and 1.20 (1.00, 1.45), p = 0.05, respectively. Higher BMI was associated with lower mortality after adjustment for waist circumference (0.48 [0.34, 0.69], p < 0.001), and higher waist circumference was more strongly associated with higher mortality after adjustment for BMI (2.18 [1.55-3.08], p < 0.001). The associations of waist circumference with mortality remained significant after additional multivariable adjustments. Higher BMI and waist circumference display opposite associations with mortality in kidney transplant recipients. Waist circumference appears to be a better prognostic marker for obesity than BMI.

Original languageEnglish (US)
Pages (from-to)2644-2651
Number of pages8
JournalAmerican Journal of Transplantation
Volume10
Issue number12
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

Fingerprint

Waist Circumference
Body Mass Index
Kidney
Mortality
Transplant Recipients
Muscles
Intra-Abdominal Fat
Subcutaneous Fat
Adiposity
Chronic Renal Insufficiency
Proportional Hazards Models
Obesity
Fats
Demography

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

Body mass index, waist circumference and mortality in kidney transplant recipients. / Kovesdy, Csaba; Czira, M. E.; Rudas, A.; Ujszaszi, A.; Rosivall, L.; Novak, M.; Kalantar-Zadeh, K.; Molnar, M. Z.; Mucsi, I.

In: American Journal of Transplantation, Vol. 10, No. 12, 01.12.2010, p. 2644-2651.

Research output: Contribution to journalArticle

Kovesdy, C, Czira, ME, Rudas, A, Ujszaszi, A, Rosivall, L, Novak, M, Kalantar-Zadeh, K, Molnar, MZ & Mucsi, I 2010, 'Body mass index, waist circumference and mortality in kidney transplant recipients', American Journal of Transplantation, vol. 10, no. 12, pp. 2644-2651. https://doi.org/10.1111/j.1600-6143.2010.03330.x
Kovesdy, Csaba ; Czira, M. E. ; Rudas, A. ; Ujszaszi, A. ; Rosivall, L. ; Novak, M. ; Kalantar-Zadeh, K. ; Molnar, M. Z. ; Mucsi, I. / Body mass index, waist circumference and mortality in kidney transplant recipients. In: American Journal of Transplantation. 2010 ; Vol. 10, No. 12. pp. 2644-2651.
@article{e59e7ac884f44a948586fcb4f51dc226,
title = "Body mass index, waist circumference and mortality in kidney transplant recipients",
abstract = "Higher body mass index (BMI) appears paradoxically associated with better outcomes in patients with chronic kidney disease. Whereas higher BMI reflects both increased visceral and subcutaneous fat and/or muscle mass, a combined assessment of BMI and waist circumference may enable differentiation of visceral adiposity from muscle and/or nonvisceral fat mass. We examined the association of BMI and waist circumference with all-cause mortality in a prospective cohort of 993 kidney transplant recipients. Associations were examined in Cox models with adjustment for demographic and comorbid conditions and for inflammatory markers. Unadjusted death hazard ratios (95{\%}CI) associated with one standard deviation higher BMI and waist circumference were 0.94 (0.78, 1.13), p = 0.5 and 1.20 (1.00, 1.45), p = 0.05, respectively. Higher BMI was associated with lower mortality after adjustment for waist circumference (0.48 [0.34, 0.69], p < 0.001), and higher waist circumference was more strongly associated with higher mortality after adjustment for BMI (2.18 [1.55-3.08], p < 0.001). The associations of waist circumference with mortality remained significant after additional multivariable adjustments. Higher BMI and waist circumference display opposite associations with mortality in kidney transplant recipients. Waist circumference appears to be a better prognostic marker for obesity than BMI.",
author = "Csaba Kovesdy and Czira, {M. E.} and A. Rudas and A. Ujszaszi and L. Rosivall and M. Novak and K. Kalantar-Zadeh and Molnar, {M. Z.} and I. Mucsi",
year = "2010",
month = "12",
day = "1",
doi = "10.1111/j.1600-6143.2010.03330.x",
language = "English (US)",
volume = "10",
pages = "2644--2651",
journal = "American Journal of Transplantation",
issn = "1600-6135",
publisher = "Wiley-Blackwell",
number = "12",

}

TY - JOUR

T1 - Body mass index, waist circumference and mortality in kidney transplant recipients

AU - Kovesdy, Csaba

AU - Czira, M. E.

AU - Rudas, A.

AU - Ujszaszi, A.

AU - Rosivall, L.

AU - Novak, M.

AU - Kalantar-Zadeh, K.

AU - Molnar, M. Z.

AU - Mucsi, I.

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Higher body mass index (BMI) appears paradoxically associated with better outcomes in patients with chronic kidney disease. Whereas higher BMI reflects both increased visceral and subcutaneous fat and/or muscle mass, a combined assessment of BMI and waist circumference may enable differentiation of visceral adiposity from muscle and/or nonvisceral fat mass. We examined the association of BMI and waist circumference with all-cause mortality in a prospective cohort of 993 kidney transplant recipients. Associations were examined in Cox models with adjustment for demographic and comorbid conditions and for inflammatory markers. Unadjusted death hazard ratios (95%CI) associated with one standard deviation higher BMI and waist circumference were 0.94 (0.78, 1.13), p = 0.5 and 1.20 (1.00, 1.45), p = 0.05, respectively. Higher BMI was associated with lower mortality after adjustment for waist circumference (0.48 [0.34, 0.69], p < 0.001), and higher waist circumference was more strongly associated with higher mortality after adjustment for BMI (2.18 [1.55-3.08], p < 0.001). The associations of waist circumference with mortality remained significant after additional multivariable adjustments. Higher BMI and waist circumference display opposite associations with mortality in kidney transplant recipients. Waist circumference appears to be a better prognostic marker for obesity than BMI.

AB - Higher body mass index (BMI) appears paradoxically associated with better outcomes in patients with chronic kidney disease. Whereas higher BMI reflects both increased visceral and subcutaneous fat and/or muscle mass, a combined assessment of BMI and waist circumference may enable differentiation of visceral adiposity from muscle and/or nonvisceral fat mass. We examined the association of BMI and waist circumference with all-cause mortality in a prospective cohort of 993 kidney transplant recipients. Associations were examined in Cox models with adjustment for demographic and comorbid conditions and for inflammatory markers. Unadjusted death hazard ratios (95%CI) associated with one standard deviation higher BMI and waist circumference were 0.94 (0.78, 1.13), p = 0.5 and 1.20 (1.00, 1.45), p = 0.05, respectively. Higher BMI was associated with lower mortality after adjustment for waist circumference (0.48 [0.34, 0.69], p < 0.001), and higher waist circumference was more strongly associated with higher mortality after adjustment for BMI (2.18 [1.55-3.08], p < 0.001). The associations of waist circumference with mortality remained significant after additional multivariable adjustments. Higher BMI and waist circumference display opposite associations with mortality in kidney transplant recipients. Waist circumference appears to be a better prognostic marker for obesity than BMI.

UR - http://www.scopus.com/inward/record.url?scp=78649845904&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649845904&partnerID=8YFLogxK

U2 - 10.1111/j.1600-6143.2010.03330.x

DO - 10.1111/j.1600-6143.2010.03330.x

M3 - Article

VL - 10

SP - 2644

EP - 2651

JO - American Journal of Transplantation

JF - American Journal of Transplantation

SN - 1600-6135

IS - 12

ER -