Bone mineral density patterns in vitamin D deficient african american men with sickle cell disease

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Abstract

OBJECTIVE:: To describe bone mineral density (BMD) patterns by densitometry in adult African American (AA) men with sickle cell disease (SCD) who are vitamin D deficient (Vit DD). INCLUSION/EXCLUSION CRITERIA:: All SCD phenotypes were eligible. Those with chronic renal failure or hyperparathyroidism were excluded. DATA COLLECTION:: Demographics, body mass index and SCD genotype. LABORATORY:: Albumin, ferritin, calcium, phosphorus, 25-hydroxy vitamin D and intact-parathyroid hormone were obtained. BMD, T and Z scores: T scores at the lumbar spine were used to categorize normal, osteopenia and osteoporosis based on World Health Organization criteria. STATISTICAL ANALYSES:: Mean ± standard deviation was used to describe continuous data, whereas categorical data were described by counts and percentages. The χ test was used to analyze categorical variables; Student's t test or one-way analysis of variance, when appropriate, was used to compare continuous variables. Rates of osteopenia-osteoporosis were determined, and the parameter with 95% confidence interval (CI) of a proportion was constructed. All tests were 2-sided, and a P ≤ 0.05 was considered statistically significant. We used StatView Version 5.01 (SAS institute Inc, Cary, NC) for the statistical analysis. RESULTS:: Seventy-eight AA men with SCD disease and Vit DD were enrolled in this study. We found that 42% of the men studied had low-BMD (osteopenia or osteoporosis) using T scores at the lumbar spine to establish densitometry strata. The prevalence of osteoporosis was 14%. CONCLUSIONS:: A large proportion of adult AA men with SCD and Vit DD showed low BMD.

Original languageEnglish (US)
Pages (from-to)262-266
Number of pages5
JournalAmerican Journal of the Medical Sciences
Volume347
Issue number4
DOIs
StatePublished - Jan 1 2014

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Sickle Cell Anemia
Vitamin D
African Americans
Bone Density
Osteoporosis
Metabolic Bone Diseases
Densitometry
Spine
Hyperparathyroidism
Ferritins
Parathyroid Hormone
Phosphorus
Chronic Kidney Failure
Albumins
Analysis of Variance
Body Mass Index
Genotype
Demography
Confidence Intervals
Students

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Bone mineral density patterns in vitamin D deficient african american men with sickle cell disease",
abstract = "OBJECTIVE:: To describe bone mineral density (BMD) patterns by densitometry in adult African American (AA) men with sickle cell disease (SCD) who are vitamin D deficient (Vit DD). INCLUSION/EXCLUSION CRITERIA:: All SCD phenotypes were eligible. Those with chronic renal failure or hyperparathyroidism were excluded. DATA COLLECTION:: Demographics, body mass index and SCD genotype. LABORATORY:: Albumin, ferritin, calcium, phosphorus, 25-hydroxy vitamin D and intact-parathyroid hormone were obtained. BMD, T and Z scores: T scores at the lumbar spine were used to categorize normal, osteopenia and osteoporosis based on World Health Organization criteria. STATISTICAL ANALYSES:: Mean ± standard deviation was used to describe continuous data, whereas categorical data were described by counts and percentages. The χ test was used to analyze categorical variables; Student's t test or one-way analysis of variance, when appropriate, was used to compare continuous variables. Rates of osteopenia-osteoporosis were determined, and the parameter with 95{\%} confidence interval (CI) of a proportion was constructed. All tests were 2-sided, and a P ≤ 0.05 was considered statistically significant. We used StatView Version 5.01 (SAS institute Inc, Cary, NC) for the statistical analysis. RESULTS:: Seventy-eight AA men with SCD disease and Vit DD were enrolled in this study. We found that 42{\%} of the men studied had low-BMD (osteopenia or osteoporosis) using T scores at the lumbar spine to establish densitometry strata. The prevalence of osteoporosis was 14{\%}. CONCLUSIONS:: A large proportion of adult AA men with SCD and Vit DD showed low BMD.",
author = "Patricia Adams-Graves and Daniels, {Alden B.} and Catherine Womack and Amado Freire",
year = "2014",
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T1 - Bone mineral density patterns in vitamin D deficient african american men with sickle cell disease

AU - Adams-Graves, Patricia

AU - Daniels, Alden B.

AU - Womack, Catherine

AU - Freire, Amado

PY - 2014/1/1

Y1 - 2014/1/1

N2 - OBJECTIVE:: To describe bone mineral density (BMD) patterns by densitometry in adult African American (AA) men with sickle cell disease (SCD) who are vitamin D deficient (Vit DD). INCLUSION/EXCLUSION CRITERIA:: All SCD phenotypes were eligible. Those with chronic renal failure or hyperparathyroidism were excluded. DATA COLLECTION:: Demographics, body mass index and SCD genotype. LABORATORY:: Albumin, ferritin, calcium, phosphorus, 25-hydroxy vitamin D and intact-parathyroid hormone were obtained. BMD, T and Z scores: T scores at the lumbar spine were used to categorize normal, osteopenia and osteoporosis based on World Health Organization criteria. STATISTICAL ANALYSES:: Mean ± standard deviation was used to describe continuous data, whereas categorical data were described by counts and percentages. The χ test was used to analyze categorical variables; Student's t test or one-way analysis of variance, when appropriate, was used to compare continuous variables. Rates of osteopenia-osteoporosis were determined, and the parameter with 95% confidence interval (CI) of a proportion was constructed. All tests were 2-sided, and a P ≤ 0.05 was considered statistically significant. We used StatView Version 5.01 (SAS institute Inc, Cary, NC) for the statistical analysis. RESULTS:: Seventy-eight AA men with SCD disease and Vit DD were enrolled in this study. We found that 42% of the men studied had low-BMD (osteopenia or osteoporosis) using T scores at the lumbar spine to establish densitometry strata. The prevalence of osteoporosis was 14%. CONCLUSIONS:: A large proportion of adult AA men with SCD and Vit DD showed low BMD.

AB - OBJECTIVE:: To describe bone mineral density (BMD) patterns by densitometry in adult African American (AA) men with sickle cell disease (SCD) who are vitamin D deficient (Vit DD). INCLUSION/EXCLUSION CRITERIA:: All SCD phenotypes were eligible. Those with chronic renal failure or hyperparathyroidism were excluded. DATA COLLECTION:: Demographics, body mass index and SCD genotype. LABORATORY:: Albumin, ferritin, calcium, phosphorus, 25-hydroxy vitamin D and intact-parathyroid hormone were obtained. BMD, T and Z scores: T scores at the lumbar spine were used to categorize normal, osteopenia and osteoporosis based on World Health Organization criteria. STATISTICAL ANALYSES:: Mean ± standard deviation was used to describe continuous data, whereas categorical data were described by counts and percentages. The χ test was used to analyze categorical variables; Student's t test or one-way analysis of variance, when appropriate, was used to compare continuous variables. Rates of osteopenia-osteoporosis were determined, and the parameter with 95% confidence interval (CI) of a proportion was constructed. All tests were 2-sided, and a P ≤ 0.05 was considered statistically significant. We used StatView Version 5.01 (SAS institute Inc, Cary, NC) for the statistical analysis. RESULTS:: Seventy-eight AA men with SCD disease and Vit DD were enrolled in this study. We found that 42% of the men studied had low-BMD (osteopenia or osteoporosis) using T scores at the lumbar spine to establish densitometry strata. The prevalence of osteoporosis was 14%. CONCLUSIONS:: A large proportion of adult AA men with SCD and Vit DD showed low BMD.

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JO - American Journal of the Medical Sciences

JF - American Journal of the Medical Sciences

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