Bone morphology in 46 BXD recombinant inbred strains and femur-tibia correlation

Yueying Zhang, Jinsong Huang, Yan Jiao, Valentin David, Mehmet Kocak, Esra Roan, Denis Diangelo, Lu Lu, Karen Hasty, Weikuan Gu

Research output: Contribution to journalArticle

Abstract

We examined the bone properties of BXD recombinant inbred (RI) mice by analyzing femur and tibia and compared their phenotypes of different compartments. 46 BXD RI mouse strains were analyzed including progenitor C57BL/6J (n=16) and DBA/2J (n=15) and two first filial generations (D2B6F1 and B6D2F1). Strain differences were observed in bone quality and structural properties (P<0.05) in each bone profile (whole bone, cortical bone, or trabecular bone). It is well known that skeletal phenotypes are largely affected by genetic determinants and genders, such as bone mineral density (BMD). While genetics and gender appear expectedly as the major determinants of bone mass and structure, significant correlations were also observed between femur and tibia. More importantly, positive and negative femur-tibia associations indicated that genetic makeup had an influence on skeletal integrity. We conclude that (a) femur-tibia association in bone morphological properties significantly varies from strain to strain, which may be caused by genetic differences among strains, and (b) strainwise variations were seen in bone mass, bone morphology, and bone microarchitecture along with bone structural property.

Original languageEnglish (US)
Article number728278
JournalScientific World Journal
Volume2015
DOIs
StatePublished - Feb 25 2015

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Tibia
Femur
bone
Bone
Bone and Bones
phenotype
Structural properties
Phenotype
gender
Inbred Strains Mice
Bone Density
Minerals

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

Cite this

Bone morphology in 46 BXD recombinant inbred strains and femur-tibia correlation. / Zhang, Yueying; Huang, Jinsong; Jiao, Yan; David, Valentin; Kocak, Mehmet; Roan, Esra; Diangelo, Denis; Lu, Lu; Hasty, Karen; Gu, Weikuan.

In: Scientific World Journal, Vol. 2015, 728278, 25.02.2015.

Research output: Contribution to journalArticle

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AU - Jiao, Yan

AU - David, Valentin

AU - Kocak, Mehmet

AU - Roan, Esra

AU - Diangelo, Denis

AU - Lu, Lu

AU - Hasty, Karen

AU - Gu, Weikuan

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