Boron trihalide-promoted addition of aryl aldehydes to styrenes. A new convenient and highly efficient synthesis of 1,3-dihalo-1,3-diarylpropanes

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Abstract

Reactions of aryl aldehydes with styrenes in the presence of boron trichloride in CH2Cl2 at 0°C produce 1,3-dichloro-1,3-diarylpropanes in excellent yields. Reactions carried out using boron tribromide generate the corresponding 1,3-dibromo-1,3-diarylpropane in good yields.

Original languageEnglish (US)
Pages (from-to)5793-5796
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number34
DOIs
StatePublished - Aug 20 2001

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Styrenes
Boron
Aldehydes
boron trichloride

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

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title = "Boron trihalide-promoted addition of aryl aldehydes to styrenes. A new convenient and highly efficient synthesis of 1,3-dihalo-1,3-diarylpropanes",
abstract = "Reactions of aryl aldehydes with styrenes in the presence of boron trichloride in CH2Cl2 at 0°C produce 1,3-dichloro-1,3-diarylpropanes in excellent yields. Reactions carried out using boron tribromide generate the corresponding 1,3-dibromo-1,3-diarylpropane in good yields.",
author = "George Kabalka and Zhongzhi Wu and Yuhong Ju",
year = "2001",
month = "8",
day = "20",
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language = "English (US)",
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journal = "Tetrahedron Letters",
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T1 - Boron trihalide-promoted addition of aryl aldehydes to styrenes. A new convenient and highly efficient synthesis of 1,3-dihalo-1,3-diarylpropanes

AU - Kabalka, George

AU - Wu, Zhongzhi

AU - Ju, Yuhong

PY - 2001/8/20

Y1 - 2001/8/20

N2 - Reactions of aryl aldehydes with styrenes in the presence of boron trichloride in CH2Cl2 at 0°C produce 1,3-dichloro-1,3-diarylpropanes in excellent yields. Reactions carried out using boron tribromide generate the corresponding 1,3-dibromo-1,3-diarylpropane in good yields.

AB - Reactions of aryl aldehydes with styrenes in the presence of boron trichloride in CH2Cl2 at 0°C produce 1,3-dichloro-1,3-diarylpropanes in excellent yields. Reactions carried out using boron tribromide generate the corresponding 1,3-dibromo-1,3-diarylpropane in good yields.

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U2 - 10.1016/S0040-4039(01)01125-X

DO - 10.1016/S0040-4039(01)01125-X

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 34

ER -