Boron‐11 MRI and MRS of intact animals infused with a boron neutron capture agent

George Kabalka, Mark Davis, Peter Bendel

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Boron neutron capture therapy (BNCT) depends on the delivery of boron‐containing drugs to a targeted lesion. Currently, the verification and quantification of in vivo boron content is a difficult problem. Boron‐11 spectroscopy was utilized to confirm the presence of a dimeric sulfhydryl dodecaborane BNCT agent contained in an intact animal. Spectroscopy experiments revealed that the decay time of transverse magnetization of the boron‐11 spins was less than 1 ms which precluded the use of a 2DFT imaging protocol. A back‐projection protocol was developed and utilized to generate the first boron‐11 image of a BNCT agent in the liver of an intact Fisher 344 rat. © 1988 Academic Press, Inc.

Original languageEnglish (US)
Pages (from-to)231-237
Number of pages7
JournalMagnetic Resonance in Medicine
Volume8
Issue number2
DOIs
StatePublished - Jan 1 1988

Fingerprint

Boron Neutron Capture Therapy
Boron
Neutrons
Spectrum Analysis
Liver
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Boron‐11 MRI and MRS of intact animals infused with a boron neutron capture agent. / Kabalka, George; Davis, Mark; Bendel, Peter.

In: Magnetic Resonance in Medicine, Vol. 8, No. 2, 01.01.1988, p. 231-237.

Research output: Contribution to journalArticle

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