Boronated unnatural cyclic amino acids as potential delivery agents for neutron capture therapy

George Kabalka, Aarif L. Shaikh, Rolf F. Barth, Tianyao Huo, Weilian Yang, Pamela M. Gordnier, Subhash Chandra

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Boron delivery characteristics of cis and trans isomers of a boronated unnatural amino acid, 1-amino-3-boronocyclopentanecarboxylic acid (ABCPC) were tested in the B16 mouse model for human melanoma. Both ABCPC isomers delivered comparable boron to B16 melanoma tumor cells as l- p-boronophenylalanine (BPA). Secondary ion mass spectrometry (SIMS) analysis revealed the presence of boron throughout the tumor from these compounds, and a near homogeneous distribution between the nucleus and cytoplasm of B16 cells grown in vitro. These encouraging observations support further studies of these new boron carriers in BNCT.

Original languageEnglish (US)
Pages (from-to)1778-1781
Number of pages4
JournalApplied Radiation and Isotopes
Volume69
Issue number12
DOIs
StatePublished - Dec 1 2011
Externally publishedYes

Fingerprint

amino acids
therapy
delivery
boron
neutrons
tumors
isomers
acids
cytoplasm
secondary ion mass spectrometry
mice
nuclei

All Science Journal Classification (ASJC) codes

  • Radiation

Cite this

Boronated unnatural cyclic amino acids as potential delivery agents for neutron capture therapy. / Kabalka, George; Shaikh, Aarif L.; Barth, Rolf F.; Huo, Tianyao; Yang, Weilian; Gordnier, Pamela M.; Chandra, Subhash.

In: Applied Radiation and Isotopes, Vol. 69, No. 12, 01.12.2011, p. 1778-1781.

Research output: Contribution to journalArticle

Kabalka, George ; Shaikh, Aarif L. ; Barth, Rolf F. ; Huo, Tianyao ; Yang, Weilian ; Gordnier, Pamela M. ; Chandra, Subhash. / Boronated unnatural cyclic amino acids as potential delivery agents for neutron capture therapy. In: Applied Radiation and Isotopes. 2011 ; Vol. 69, No. 12. pp. 1778-1781.
@article{908b373ab0414a9bb828456d6dca2dac,
title = "Boronated unnatural cyclic amino acids as potential delivery agents for neutron capture therapy",
abstract = "Boron delivery characteristics of cis and trans isomers of a boronated unnatural amino acid, 1-amino-3-boronocyclopentanecarboxylic acid (ABCPC) were tested in the B16 mouse model for human melanoma. Both ABCPC isomers delivered comparable boron to B16 melanoma tumor cells as l- p-boronophenylalanine (BPA). Secondary ion mass spectrometry (SIMS) analysis revealed the presence of boron throughout the tumor from these compounds, and a near homogeneous distribution between the nucleus and cytoplasm of B16 cells grown in vitro. These encouraging observations support further studies of these new boron carriers in BNCT.",
author = "George Kabalka and Shaikh, {Aarif L.} and Barth, {Rolf F.} and Tianyao Huo and Weilian Yang and Gordnier, {Pamela M.} and Subhash Chandra",
year = "2011",
month = "12",
day = "1",
doi = "10.1016/j.apradiso.2011.03.035",
language = "English (US)",
volume = "69",
pages = "1778--1781",
journal = "Applied Radiation and Isotopes",
issn = "0969-8043",
publisher = "Elsevier Limited",
number = "12",

}

TY - JOUR

T1 - Boronated unnatural cyclic amino acids as potential delivery agents for neutron capture therapy

AU - Kabalka, George

AU - Shaikh, Aarif L.

AU - Barth, Rolf F.

AU - Huo, Tianyao

AU - Yang, Weilian

AU - Gordnier, Pamela M.

AU - Chandra, Subhash

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Boron delivery characteristics of cis and trans isomers of a boronated unnatural amino acid, 1-amino-3-boronocyclopentanecarboxylic acid (ABCPC) were tested in the B16 mouse model for human melanoma. Both ABCPC isomers delivered comparable boron to B16 melanoma tumor cells as l- p-boronophenylalanine (BPA). Secondary ion mass spectrometry (SIMS) analysis revealed the presence of boron throughout the tumor from these compounds, and a near homogeneous distribution between the nucleus and cytoplasm of B16 cells grown in vitro. These encouraging observations support further studies of these new boron carriers in BNCT.

AB - Boron delivery characteristics of cis and trans isomers of a boronated unnatural amino acid, 1-amino-3-boronocyclopentanecarboxylic acid (ABCPC) were tested in the B16 mouse model for human melanoma. Both ABCPC isomers delivered comparable boron to B16 melanoma tumor cells as l- p-boronophenylalanine (BPA). Secondary ion mass spectrometry (SIMS) analysis revealed the presence of boron throughout the tumor from these compounds, and a near homogeneous distribution between the nucleus and cytoplasm of B16 cells grown in vitro. These encouraging observations support further studies of these new boron carriers in BNCT.

UR - http://www.scopus.com/inward/record.url?scp=80055087973&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80055087973&partnerID=8YFLogxK

U2 - 10.1016/j.apradiso.2011.03.035

DO - 10.1016/j.apradiso.2011.03.035

M3 - Article

VL - 69

SP - 1778

EP - 1781

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

SN - 0969-8043

IS - 12

ER -