Both cell surface and internalized β-adrenoceptors are reduced in the failing myocardium

J. Thompson Sullebarger, Tai-Hwang Fan, Fernando Torres, Chang seng Liang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

To study myocardial β-adrenoceptor internalization in heart failure, we measured β-adrenoceptor density in the particulate, light vesicle and supernatant fractions of ventricular tissue of dogs with experimental right ventricular failure and sham-operated dogs. Tissue was fractionated by centrifugation, and β-adrenoceptors were measured by [125I]iodocyanopindolol binding. Compared to sham-operated controls, β-adrenoccptors were reduced in all fractions of right ventricular tissue from heart failure animals. Thus, the decreased surface (particulate fraction) receptors observed cannot be explained by internalization alone, and must be associated with altered receptor synthesis or degradation.

Original languageEnglish (US)
Pages (from-to)165-169
Number of pages5
JournalEuropean Journal of Pharmacology
Volume205
Issue number2
DOIs
StatePublished - Nov 26 1991
Externally publishedYes

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Adrenergic Receptors
Myocardium
Heart Failure
Iodocyanopindolol
Dogs
Centrifugation
Light

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Both cell surface and internalized β-adrenoceptors are reduced in the failing myocardium. / Sullebarger, J. Thompson; Fan, Tai-Hwang; Torres, Fernando; Liang, Chang seng.

In: European Journal of Pharmacology, Vol. 205, No. 2, 26.11.1991, p. 165-169.

Research output: Contribution to journalArticle

Sullebarger, J. Thompson ; Fan, Tai-Hwang ; Torres, Fernando ; Liang, Chang seng. / Both cell surface and internalized β-adrenoceptors are reduced in the failing myocardium. In: European Journal of Pharmacology. 1991 ; Vol. 205, No. 2. pp. 165-169.
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