Brain insulin controls adipose tissue lipolysis and lipogenesis

Thomas Scherer, James OHare, Kelly Diggs-Andrews, Martina Schweiger, Bob Cheng, Claudia Lindtner, Elizabeth Zielinski, Prashant Vempati, Kai Su, Shveta Dighe, Thomas Milsom, Michelle Puchowicz, Ludger Scheja, Rudolf Zechner, Simon J. Fisher, Stephen F. Previs, Christoph Buettner

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

White adipose tissue (WAT) dysfunction plays a key role in the pathogenesis of type 2 diabetes (DM2). Unrestrained WAT lipolysis results in increased fatty acid release, leading to insulin resistance and lipotoxicity, while impaired de novo lipogenesis in WAT decreases the synthesis of insulin-sensitizing fatty acid species like palmitoleate. Here, we show that insulin infused into the mediobasal hypothalamus (MBH) of Sprague-Dawley rats increases WAT lipogenic protein expression, inactivates hormone-sensitive lipase (Hsl), and suppresses lipolysis. Conversely, mice that lack the neuronal insulin receptor exhibit unrestrained lipolysis and decreased de novo lipogenesis in WAT. Thus, brain and, in particular, hypothalamic insulin action play a pivotal role in WAT functionality.

Original languageEnglish (US)
Pages (from-to)183-194
Number of pages12
JournalCell Metabolism
Volume13
Issue number2
DOIs
StatePublished - Feb 2 2011
Externally publishedYes

Fingerprint

White Adipose Tissue
Lipogenesis
Lipolysis
Adipose Tissue
Insulin
Brain
Fatty Acids
Sterol Esterase
Insulin Receptor
Type 2 Diabetes Mellitus
Hypothalamus
Sprague Dawley Rats
Insulin Resistance
Proteins

All Science Journal Classification (ASJC) codes

  • Physiology
  • Molecular Biology
  • Cell Biology

Cite this

Scherer, T., OHare, J., Diggs-Andrews, K., Schweiger, M., Cheng, B., Lindtner, C., ... Buettner, C. (2011). Brain insulin controls adipose tissue lipolysis and lipogenesis. Cell Metabolism, 13(2), 183-194. https://doi.org/10.1016/j.cmet.2011.01.008

Brain insulin controls adipose tissue lipolysis and lipogenesis. / Scherer, Thomas; OHare, James; Diggs-Andrews, Kelly; Schweiger, Martina; Cheng, Bob; Lindtner, Claudia; Zielinski, Elizabeth; Vempati, Prashant; Su, Kai; Dighe, Shveta; Milsom, Thomas; Puchowicz, Michelle; Scheja, Ludger; Zechner, Rudolf; Fisher, Simon J.; Previs, Stephen F.; Buettner, Christoph.

In: Cell Metabolism, Vol. 13, No. 2, 02.02.2011, p. 183-194.

Research output: Contribution to journalArticle

Scherer, T, OHare, J, Diggs-Andrews, K, Schweiger, M, Cheng, B, Lindtner, C, Zielinski, E, Vempati, P, Su, K, Dighe, S, Milsom, T, Puchowicz, M, Scheja, L, Zechner, R, Fisher, SJ, Previs, SF & Buettner, C 2011, 'Brain insulin controls adipose tissue lipolysis and lipogenesis', Cell Metabolism, vol. 13, no. 2, pp. 183-194. https://doi.org/10.1016/j.cmet.2011.01.008
Scherer T, OHare J, Diggs-Andrews K, Schweiger M, Cheng B, Lindtner C et al. Brain insulin controls adipose tissue lipolysis and lipogenesis. Cell Metabolism. 2011 Feb 2;13(2):183-194. https://doi.org/10.1016/j.cmet.2011.01.008
Scherer, Thomas ; OHare, James ; Diggs-Andrews, Kelly ; Schweiger, Martina ; Cheng, Bob ; Lindtner, Claudia ; Zielinski, Elizabeth ; Vempati, Prashant ; Su, Kai ; Dighe, Shveta ; Milsom, Thomas ; Puchowicz, Michelle ; Scheja, Ludger ; Zechner, Rudolf ; Fisher, Simon J. ; Previs, Stephen F. ; Buettner, Christoph. / Brain insulin controls adipose tissue lipolysis and lipogenesis. In: Cell Metabolism. 2011 ; Vol. 13, No. 2. pp. 183-194.
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