Brain Mechanisms for Reading and Language Processing in Spina Bifida Meningomyelocele

A Combined Magnetic Source- and Structural Magnetic Resonance Imaging Meningomyelocele Study

Panagiotis G. Simos, Andrew Papanicolaou, Eduardo Martinez Castillo, Jenifer Juranek, Paul T. Cirino, Roozbeh Rezaie, Jack M. Fletcher

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: The development of the ability to process spoken and written language depends upon a network of left hemisphere temporal, parietal, and frontal regions. The present study explored features of brain organization in children with spina bifida meningomyelocele (SBM) and shunted hydrocephalus, who commonly present with precocious development of word reading skills and preservation of vocabulary and grammar skills. Method: Eight children with SBM were compared with 15 IQ and reading-level matched, typically developing controls on MRI-based morphometric and Magnetic Source Imaging-derived neurophysiological profiles. Results: Children with SBM showed reduced magnetic activity in left inferior parietal regions during spoken word recognition and pseudoword reading tasks. We also noted reduced surface area/volume in inferior parietal and posterior temporal regions in SBM and increased gray matter volumes in left middle frontal regions and gyral complexity in left posterior temporal and inferior parietal regions. Conclusions: A complex pattern of changes in cortical morphology and activation may serve as evidence for structural and functional brain reorganization ensuring preservation of language and decoding abilities in children with SBM.

Original languageEnglish (US)
Pages (from-to)590-601
Number of pages12
JournalNeuropsychology
Volume25
Issue number5
DOIs
StatePublished - Sep 1 2011

Fingerprint

Meningomyelocele
Spinal Dysraphism
Reading
Language
Parietal Lobe
Magnetic Resonance Imaging
Brain
Aptitude
Vocabulary
Temporal Lobe
Hydrocephalus

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology

Cite this

Brain Mechanisms for Reading and Language Processing in Spina Bifida Meningomyelocele : A Combined Magnetic Source- and Structural Magnetic Resonance Imaging Meningomyelocele Study. / Simos, Panagiotis G.; Papanicolaou, Andrew; Castillo, Eduardo Martinez; Juranek, Jenifer; Cirino, Paul T.; Rezaie, Roozbeh; Fletcher, Jack M.

In: Neuropsychology, Vol. 25, No. 5, 01.09.2011, p. 590-601.

Research output: Contribution to journalArticle

Simos, Panagiotis G. ; Papanicolaou, Andrew ; Castillo, Eduardo Martinez ; Juranek, Jenifer ; Cirino, Paul T. ; Rezaie, Roozbeh ; Fletcher, Jack M. / Brain Mechanisms for Reading and Language Processing in Spina Bifida Meningomyelocele : A Combined Magnetic Source- and Structural Magnetic Resonance Imaging Meningomyelocele Study. In: Neuropsychology. 2011 ; Vol. 25, No. 5. pp. 590-601.
@article{9f3976ef081d4d3186cb8c31e73e173d,
title = "Brain Mechanisms for Reading and Language Processing in Spina Bifida Meningomyelocele: A Combined Magnetic Source- and Structural Magnetic Resonance Imaging Meningomyelocele Study",
abstract = "Objective: The development of the ability to process spoken and written language depends upon a network of left hemisphere temporal, parietal, and frontal regions. The present study explored features of brain organization in children with spina bifida meningomyelocele (SBM) and shunted hydrocephalus, who commonly present with precocious development of word reading skills and preservation of vocabulary and grammar skills. Method: Eight children with SBM were compared with 15 IQ and reading-level matched, typically developing controls on MRI-based morphometric and Magnetic Source Imaging-derived neurophysiological profiles. Results: Children with SBM showed reduced magnetic activity in left inferior parietal regions during spoken word recognition and pseudoword reading tasks. We also noted reduced surface area/volume in inferior parietal and posterior temporal regions in SBM and increased gray matter volumes in left middle frontal regions and gyral complexity in left posterior temporal and inferior parietal regions. Conclusions: A complex pattern of changes in cortical morphology and activation may serve as evidence for structural and functional brain reorganization ensuring preservation of language and decoding abilities in children with SBM.",
author = "Simos, {Panagiotis G.} and Andrew Papanicolaou and Castillo, {Eduardo Martinez} and Jenifer Juranek and Cirino, {Paul T.} and Roozbeh Rezaie and Fletcher, {Jack M.}",
year = "2011",
month = "9",
day = "1",
doi = "10.1037/a0023694",
language = "English (US)",
volume = "25",
pages = "590--601",
journal = "Neuropsychology",
issn = "0894-4105",
publisher = "American Psychological Association Inc.",
number = "5",

}

TY - JOUR

T1 - Brain Mechanisms for Reading and Language Processing in Spina Bifida Meningomyelocele

T2 - A Combined Magnetic Source- and Structural Magnetic Resonance Imaging Meningomyelocele Study

AU - Simos, Panagiotis G.

AU - Papanicolaou, Andrew

AU - Castillo, Eduardo Martinez

AU - Juranek, Jenifer

AU - Cirino, Paul T.

AU - Rezaie, Roozbeh

AU - Fletcher, Jack M.

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Objective: The development of the ability to process spoken and written language depends upon a network of left hemisphere temporal, parietal, and frontal regions. The present study explored features of brain organization in children with spina bifida meningomyelocele (SBM) and shunted hydrocephalus, who commonly present with precocious development of word reading skills and preservation of vocabulary and grammar skills. Method: Eight children with SBM were compared with 15 IQ and reading-level matched, typically developing controls on MRI-based morphometric and Magnetic Source Imaging-derived neurophysiological profiles. Results: Children with SBM showed reduced magnetic activity in left inferior parietal regions during spoken word recognition and pseudoword reading tasks. We also noted reduced surface area/volume in inferior parietal and posterior temporal regions in SBM and increased gray matter volumes in left middle frontal regions and gyral complexity in left posterior temporal and inferior parietal regions. Conclusions: A complex pattern of changes in cortical morphology and activation may serve as evidence for structural and functional brain reorganization ensuring preservation of language and decoding abilities in children with SBM.

AB - Objective: The development of the ability to process spoken and written language depends upon a network of left hemisphere temporal, parietal, and frontal regions. The present study explored features of brain organization in children with spina bifida meningomyelocele (SBM) and shunted hydrocephalus, who commonly present with precocious development of word reading skills and preservation of vocabulary and grammar skills. Method: Eight children with SBM were compared with 15 IQ and reading-level matched, typically developing controls on MRI-based morphometric and Magnetic Source Imaging-derived neurophysiological profiles. Results: Children with SBM showed reduced magnetic activity in left inferior parietal regions during spoken word recognition and pseudoword reading tasks. We also noted reduced surface area/volume in inferior parietal and posterior temporal regions in SBM and increased gray matter volumes in left middle frontal regions and gyral complexity in left posterior temporal and inferior parietal regions. Conclusions: A complex pattern of changes in cortical morphology and activation may serve as evidence for structural and functional brain reorganization ensuring preservation of language and decoding abilities in children with SBM.

UR - http://www.scopus.com/inward/record.url?scp=80052232034&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052232034&partnerID=8YFLogxK

U2 - 10.1037/a0023694

DO - 10.1037/a0023694

M3 - Article

VL - 25

SP - 590

EP - 601

JO - Neuropsychology

JF - Neuropsychology

SN - 0894-4105

IS - 5

ER -