Brain metabolic adaptations to hypoxia

Michelle Puchowicz, Smruta S. Koppaka, Joseph C. LaManna

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

The mammalian brain depends totally on a continuous supply of oxygen to maintain its function. It is well known that in the brain, adaptation to hypoxia occurs through both systemic and vascular changes, which may include metabolic changes. However, the local metabolic changes related to energy metabolism that occur within the cell are not well described (Harik et al., 1994; Harik et al., 1995; LaManna and Harik, 1997). Investigating the metabolic adaptations of the central nervous system to mild hypoxia provides an understanding of the key components responsible for regulating cell survival. This chapter concerns itself with the metabolic responses of the brain to mild hypoxia, that is, to physiological hypoxia. This is the range of hypoxia that can be compensated for with physiological mechanisms that directly or indirectly involve energy related metabolic pathways.

Original languageEnglish (US)
Title of host publicationMetabolic Encephalopathy
PublisherSpringer New York
Pages15-30
Number of pages16
ISBN (Electronic)9780387791128
ISBN (Print)9780387791098
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

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Brain
Metabolic Networks and Pathways
Energy Metabolism
Blood Vessels
Cell Survival
Central Nervous System
Hypoxia
Oxygen

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)

Cite this

Puchowicz, M., Koppaka, S. S., & LaManna, J. C. (2009). Brain metabolic adaptations to hypoxia. In Metabolic Encephalopathy (pp. 15-30). Springer New York. https://doi.org/10.1007/978-0-387-79112-8_2

Brain metabolic adaptations to hypoxia. / Puchowicz, Michelle; Koppaka, Smruta S.; LaManna, Joseph C.

Metabolic Encephalopathy. Springer New York, 2009. p. 15-30.

Research output: Chapter in Book/Report/Conference proceedingChapter

Puchowicz, M, Koppaka, SS & LaManna, JC 2009, Brain metabolic adaptations to hypoxia. in Metabolic Encephalopathy. Springer New York, pp. 15-30. https://doi.org/10.1007/978-0-387-79112-8_2
Puchowicz M, Koppaka SS, LaManna JC. Brain metabolic adaptations to hypoxia. In Metabolic Encephalopathy. Springer New York. 2009. p. 15-30 https://doi.org/10.1007/978-0-387-79112-8_2
Puchowicz, Michelle ; Koppaka, Smruta S. ; LaManna, Joseph C. / Brain metabolic adaptations to hypoxia. Metabolic Encephalopathy. Springer New York, 2009. pp. 15-30
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