Brain spectrin (240/235) and brain spectrin (240/235E): Two distinct spectrin subtypes with different locations within mammalian neural cells

B. M. Riederer, I. S. Zagon, Steven Goodman

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

Adult mouse brain contains at least two distinct spectrin subtypes, both consisting of 240-kD and 235-kD subunits. Brain spectrin(240/235) is found in neuronal axons, but not dendrites, when immunohistochemistry is performed with antibody raised against brain spectrin isolated from enriched synaptic/axonal membranes. A second spectrin subtype, brain spectrin(240/235E), is exclusively recognized by red blood cell spectrin antibody. Brain spectrin (240/235E) is confined to neuronal cell bodies and dendrites, and some glial cells, but is not present in axons or presynaptic terminals.

Original languageEnglish (US)
Pages (from-to)2088-2097
Number of pages10
JournalJournal of Cell Biology
Volume102
Issue number6
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

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Spectrin
Brain
Presynaptic Terminals
Dendrites
Synaptic Membranes
Antibodies
Neuroglia
Axons
Erythrocytes
Immunohistochemistry

All Science Journal Classification (ASJC) codes

  • Cell Biology

Cite this

Brain spectrin (240/235) and brain spectrin (240/235E) : Two distinct spectrin subtypes with different locations within mammalian neural cells. / Riederer, B. M.; Zagon, I. S.; Goodman, Steven.

In: Journal of Cell Biology, Vol. 102, No. 6, 01.01.1986, p. 2088-2097.

Research output: Contribution to journalArticle

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