Brain spectrin

Of mice and men

Steven Goodman, Warren E. Zimmer, Mary Blair Clark, Ian S. Zagon, Jane E. Barker, Michael L. Bloom

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

This article reviews our current knowledge of the structure of α spectrins and β spectrins in the brain, as well as their location and expression within neural tissue. We discuss the known protein interactions of brain spectrin isoforms, and then describe results that suggest an important role for spectrin (αSpIIΣ1/βSpIIΣ1) in the Ca2+-regulated release of neurotransmitters. Evidence that supports a role for spectrin in the docking of synaptic vesicles to the presynaptic plasma membrane and as a Ca2+ sensor protein that uanclamps the fusion machinery is desaibed, along with the Casting the Line model, which summarizes the information. We finish with a discussion of the value of spectrin and ankyrin-deficient mouse models in deciphering spectrin function in neural tissue.

Original languageEnglish (US)
Pages (from-to)593-606
Number of pages14
JournalBrain Research Bulletin
Volume36
Issue number6
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

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Spectrin
Brain
Ankyrins
Synaptic Vesicles
Neurotransmitter Agents
Protein Isoforms
Proteins
Cell Membrane

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Goodman, S., Zimmer, W. E., Blair Clark, M., Zagon, I. S., Barker, J. E., & Bloom, M. L. (1995). Brain spectrin: Of mice and men. Brain Research Bulletin, 36(6), 593-606. https://doi.org/10.1016/0361-9230(94)00264-2

Brain spectrin : Of mice and men. / Goodman, Steven; Zimmer, Warren E.; Blair Clark, Mary; Zagon, Ian S.; Barker, Jane E.; Bloom, Michael L.

In: Brain Research Bulletin, Vol. 36, No. 6, 01.01.1995, p. 593-606.

Research output: Contribution to journalArticle

Goodman, S, Zimmer, WE, Blair Clark, M, Zagon, IS, Barker, JE & Bloom, ML 1995, 'Brain spectrin: Of mice and men', Brain Research Bulletin, vol. 36, no. 6, pp. 593-606. https://doi.org/10.1016/0361-9230(94)00264-2
Goodman S, Zimmer WE, Blair Clark M, Zagon IS, Barker JE, Bloom ML. Brain spectrin: Of mice and men. Brain Research Bulletin. 1995 Jan 1;36(6):593-606. https://doi.org/10.1016/0361-9230(94)00264-2
Goodman, Steven ; Zimmer, Warren E. ; Blair Clark, Mary ; Zagon, Ian S. ; Barker, Jane E. ; Bloom, Michael L. / Brain spectrin : Of mice and men. In: Brain Research Bulletin. 1995 ; Vol. 36, No. 6. pp. 593-606.
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