Brainstem afferents of the cholinoceptive pontine wave generation sites in the rat

Subimal Datta, Elissa H. Patterson, Donald F. Siwek

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The present study was designed to investigate the distribution of brainstem neurons projecting to the pontine wave (P-wave)-generating sites in the rat. In six rats, biotinylated dextran amine (BDA) was microinjected into the physiologically identified cholinoceptive P-wave generation site. In all cases, microinjections of BDA in the cholinoceptive P-wave generating site resulted in retrograde labeling of cell bodies in many parts of the brainstem. The majority of those retrogradely labeled cells were in the pedunculopontine tegmentum, pontine reticular nucleus oralis, parabrachial nucleus, vestibular nucleus, and gigantocellular reticular nucleus. The results presented in this study provide anatomical evidence that the cholinoceptive P-wave generation site in the rat receives anatomical projections from other parts of the brainstem known to be involved in the REM sleep-generation mechanism.

Original languageEnglish (US)
Pages (from-to)79-82
Number of pages4
JournalSleep Research Online
Volume2
Issue number3
StatePublished - Dec 1 1999

Fingerprint

Brain Stem
Vestibular Nuclei
REM Sleep
Microinjections
Neurons
biotinylated dextran amine
Parabrachial Nucleus
Cell Body
Pontine Tegmentum

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology

Cite this

Brainstem afferents of the cholinoceptive pontine wave generation sites in the rat. / Datta, Subimal; Patterson, Elissa H.; Siwek, Donald F.

In: Sleep Research Online, Vol. 2, No. 3, 01.12.1999, p. 79-82.

Research output: Contribution to journalArticle

Datta, Subimal ; Patterson, Elissa H. ; Siwek, Donald F. / Brainstem afferents of the cholinoceptive pontine wave generation sites in the rat. In: Sleep Research Online. 1999 ; Vol. 2, No. 3. pp. 79-82.
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