Buspirone in the treatment of premenstrual syndrome

Candace Brown, F. W. Ling, R. G. Farmer, B. F. Stone

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A double-blind, placebo-controlled, crossover study was conducted to determine the efficacy of buspirone in the treatment of women with premenstrual syndrome (PMS). Following two months of symptom diary documentation, 19 women with a DSM-III-R diagnosis of PMS were crossed over to the alternate treatment for an additional two cycles. Placebo washouts were incorporated before randomization and between treatments. Results indicate that buspirone is significantly more effective than placebo in relieving premenstrual anxiety, irritability, and depression. The lack of sedation and dependency potential of buspirone (BuSpar) may make the drug an important alternative to other PMS therapies.

Original languageEnglish (US)
Pages (from-to)112-121
Number of pages10
JournalDrug Therapy
Volume20
Issue numberSUPPL.
StatePublished - 1990

Fingerprint

Buspirone
Premenstrual Syndrome
Placebos
Therapeutics
Random Allocation
Diagnostic and Statistical Manual of Mental Disorders
Documentation
Cross-Over Studies
Anxiety
Depression
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Brown, C., Ling, F. W., Farmer, R. G., & Stone, B. F. (1990). Buspirone in the treatment of premenstrual syndrome. Drug Therapy, 20(SUPPL.), 112-121.

Buspirone in the treatment of premenstrual syndrome. / Brown, Candace; Ling, F. W.; Farmer, R. G.; Stone, B. F.

In: Drug Therapy, Vol. 20, No. SUPPL., 1990, p. 112-121.

Research output: Contribution to journalArticle

Brown, C, Ling, FW, Farmer, RG & Stone, BF 1990, 'Buspirone in the treatment of premenstrual syndrome', Drug Therapy, vol. 20, no. SUPPL., pp. 112-121.
Brown C, Ling FW, Farmer RG, Stone BF. Buspirone in the treatment of premenstrual syndrome. Drug Therapy. 1990;20(SUPPL.):112-121.
Brown, Candace ; Ling, F. W. ; Farmer, R. G. ; Stone, B. F. / Buspirone in the treatment of premenstrual syndrome. In: Drug Therapy. 1990 ; Vol. 20, No. SUPPL. pp. 112-121.
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