BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor model

William E. Grizzle, John D. Mountz, Ping Ar Yang, Xin Xu, Sheher Sun, Gary E. Van Zant, Robert Williams, Hui Chen Hsu, Huang Ge Zhang

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Abstract

To develop a better animal model for studying the effects of the host environment in neoplasia, we injected various genetically well-characterized H-2d RI strains of BXD mice with syngeneic breast cancer cells (TS/A) and monitored the growth of tumors over time. There was a marked difference in the growth of the implanted breast cancer cells among the 14 BXD RI strains, with 4 patterns of tumor development being observed: in type I, the implanted tumor cells grew rapidly in the first 2 weeks, necrosis of the tumors was observed and metastases to the intestinal lymph nodes and pancreas was observed, causing death; in type II, the implanted tumor cells grew slowly and attained a size after day 50 that required killing the animal, with tumor necrosis being rare and metastases absent; in type III, the implanted tumor cells grew initially but underwent a slow decline after 4 weeks; and in type IV, the implanted tumor cells failed to develop. Apoptosis of the implanted tumor cells was responsible for the regression of tumor nodules. The T-cell immune response minimized tumor development in types III and IV since T-cell depletion of the BXD RI mice resulted in aggressively growing tumors in these strains.

Original languageEnglish (US)
Pages (from-to)270-279
Number of pages10
JournalInternational Journal of Cancer
Volume101
Issue number3
DOIs
StatePublished - Sep 20 2002

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T-Lymphocytes
Neoplasms
Necrosis
Breast Neoplasms
Neoplasm Metastasis
Growth
Pancreas
Animal Models
Lymph Nodes
Apoptosis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Grizzle, W. E., Mountz, J. D., Yang, P. A., Xu, X., Sun, S., Van Zant, G. E., ... Zhang, H. G. (2002). BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor model. International Journal of Cancer, 101(3), 270-279. https://doi.org/10.1002/ijc.10606

BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor model. / Grizzle, William E.; Mountz, John D.; Yang, Ping Ar; Xu, Xin; Sun, Sheher; Van Zant, Gary E.; Williams, Robert; Hsu, Hui Chen; Zhang, Huang Ge.

In: International Journal of Cancer, Vol. 101, No. 3, 20.09.2002, p. 270-279.

Research output: Contribution to journalArticle

Grizzle, WE, Mountz, JD, Yang, PA, Xu, X, Sun, S, Van Zant, GE, Williams, R, Hsu, HC & Zhang, HG 2002, 'BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor model', International Journal of Cancer, vol. 101, no. 3, pp. 270-279. https://doi.org/10.1002/ijc.10606
Grizzle, William E. ; Mountz, John D. ; Yang, Ping Ar ; Xu, Xin ; Sun, Sheher ; Van Zant, Gary E. ; Williams, Robert ; Hsu, Hui Chen ; Zhang, Huang Ge. / BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor model. In: International Journal of Cancer. 2002 ; Vol. 101, No. 3. pp. 270-279.
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