C3.SW-SOAa heterozygous congenic taster mice

John Boughter, Glayde Whitney

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Sensitivity to the bitter acetylated sugar sucrose octaacetate (SOA) is mediated by a single-locus system with three alleles in mice. Inbred strains are classified according to SOA phenotype as tasters, nontasters, or demitasters (intermediate sensitivity). A congenic quartet created from taster and nontaster strains has been used to investigate the effect of the Soa locus on non-SOA aspects of taste sensitivity. In this study, we created a third congenic set, C3.SW-Soaa, from taster (SWR/J) and demitaster (C3HeB/FeJ) strains. After 11 lineal backcross generations these C3.SW mice carry the tasting allele on a 99% C3 demitaster background. After testing a total of 938 mice, taster-demitaster proportions across 12 generations were consistent with expectations from a monogenic model. The resultant three-strain congenic series will allow further examination of the mechanisms of taste.

Original languageEnglish (US)
Pages (from-to)233-237
Number of pages5
JournalBehavior Genetics
Volume25
Issue number3
DOIs
StatePublished - May 1 1995

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Congenic Mice
sucrose
allele
mice
Alleles
phenotype
sugar
taste sensitivity
alleles
loci
Phenotype
sugars
sucrose octaacetate
testing
effect

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)

Cite this

C3.SW-SOAa heterozygous congenic taster mice. / Boughter, John; Whitney, Glayde.

In: Behavior Genetics, Vol. 25, No. 3, 01.05.1995, p. 233-237.

Research output: Contribution to journalArticle

Boughter, John ; Whitney, Glayde. / C3.SW-SOAa heterozygous congenic taster mice. In: Behavior Genetics. 1995 ; Vol. 25, No. 3. pp. 233-237.
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