Calcineurin interacts with KIN-29, a Ser/Thr kinase, in Caenorhabditis elegans

Gunasekaran Singaravelu, Hyun O. Song, Yon J. Ji, Chang Hoon Jee, Byung J. Park, Joohong Ahnn

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Calcineurin is a Ca2+/Calmodulin activated Ser/Thr phosphatase that is well conserved from yeast to human. In Caenorhabditis elegans, tax-6 and cnb-1 encode catalytic and regulatory subunits of calcineurin, respectively. We performed yeast two-hybrid screening using TAX-6 as a bait to identify calcineurin interacting proteins. KIN-29 is one of proteins that specifically interacted with TAX-6. KIN-29 is a Ser/Thr kinase previously shown to be involved in regulating gene expression of a subset of chemoreceptors in specific neurons. Both TAX-6 and KIN-29 are expressed in hypodermis, muscles, and neurons. Moreover, both calcineurin and kin-29 mutants exhibit similar phenotypes, namely small body size, small brood size, and slow growth. Here we describe specific genetic interaction between tax-6 and kin-29 in regulating body size, serotonin mediated egg laying, and chemoreceptor expression.

Original languageEnglish (US)
Pages (from-to)29-35
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume352
Issue number1
DOIs
StatePublished - Jan 5 2007
Externally publishedYes

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Calcineurin
Caenorhabditis elegans
Phosphotransferases
Body Size
Taxation
Yeast
Neurons
Yeasts
Subcutaneous Tissue
Calmodulin
Phosphoric Monoester Hydrolases
Gene expression
Ovum
Muscle
Catalytic Domain
Serotonin
Screening
Proteins
Phenotype
Gene Expression

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Calcineurin interacts with KIN-29, a Ser/Thr kinase, in Caenorhabditis elegans. / Singaravelu, Gunasekaran; Song, Hyun O.; Ji, Yon J.; Jee, Chang Hoon; Park, Byung J.; Ahnn, Joohong.

In: Biochemical and Biophysical Research Communications, Vol. 352, No. 1, 05.01.2007, p. 29-35.

Research output: Contribution to journalArticle

Singaravelu, Gunasekaran ; Song, Hyun O. ; Ji, Yon J. ; Jee, Chang Hoon ; Park, Byung J. ; Ahnn, Joohong. / Calcineurin interacts with KIN-29, a Ser/Thr kinase, in Caenorhabditis elegans. In: Biochemical and Biophysical Research Communications. 2007 ; Vol. 352, No. 1. pp. 29-35.
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