Calcitonin gene-related peptide in human fetal lung and in neonatal lung disease

Mahlon Johnson, M. E. Gray, M. T. Stahlman

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The ontogeny of calcitonin gene-related peptide immunoreactivity (CGRP-IR) was evaluated immunohistochemically in 67 human fetal or newborn lungs previously analyzed for calcitonin immunoreactivity (CT-IR). CGRP-IR was present by 10 weeks of gestation in rare, solitary neuroendocrine (NE) cells of developing conducting airways in two of eight first-trimester lungs. During the second trimester, cells with CGRP-IR were found consistently (21/23 fetuses). However, the numbers of positively staining cells did not appear to increase in these fetuses or in third-trimester infants dying of non-pulmonary causes. The highest concentrations of CGRP-IR cells were seen in lungs of premature infants with advancing chronic lung disease associated with bronchopulmonary dysplasia (BPD). CGRP-IR was seen earlier in gestation and in greater numbers of NE cells than was calcitonin immunoreactivity (CT-IR) reported previously in these same fetal lungs (Lab Invest 52:52, 1985). Its presence paralleled that of CT-IR in postnatal chronic lung disease.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalJournal of Histochemistry and Cytochemistry
Volume36
Issue number2
DOIs
StatePublished - Jan 1 1988

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Infant, Newborn, Diseases
Calcitonin Gene-Related Peptide
Lung Diseases
Calcitonin
Lung
Neuroendocrine Cells
Fetus
Chronic Disease
Pregnancy
Bronchopulmonary Dysplasia
Third Pregnancy Trimester
Second Pregnancy Trimester
First Pregnancy Trimester
Premature Infants
Newborn Infant
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Histology

Cite this

Calcitonin gene-related peptide in human fetal lung and in neonatal lung disease. / Johnson, Mahlon; Gray, M. E.; Stahlman, M. T.

In: Journal of Histochemistry and Cytochemistry, Vol. 36, No. 2, 01.01.1988, p. 199-204.

Research output: Contribution to journalArticle

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