Calcium and vitamin D supplementation do not influence menopause-related symptoms

Results of the Women's Health Initiative Trial

Erin S. LeBlanc, Haley Hedlin, Feifei Qin, Manisha Desai, Jean Wactawski-Wende, Nancy Perrin, Joann E. Manson, Karen Johnson, Kamal Masaki, Frances Tylavsky, Marcia L. Stefanick

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: It is unknown whether supplementation with calcium and vitamin D has an impact on menopause-related symptoms. Methods: As part of the Women's Health Initiative Calcium/Vitamin D Supplementation Trial (CaD), women were randomized at 40 clinical sites to elemental calcium carbonate 1000 mg with vitamin D 400 IU daily or placebo. At the CaD baseline visit (year 1 or year 2) and during a mean follow-up of 5.7 years, participants provided data on menopause-related symptoms via questionnaires. Generalized linear mixed effects techniques were used to address research questions. Results: After excluding participants with missing data (N = 2125), we compared menopause-related symptoms at follow-up visits of 17,101 women randomized to CaD with those of 17,056 women given the placebo. Women in the CaD arm did not have a different number of symptoms at follow-up compared to women taking the placebo (p = 0.702). Similarly, there was no difference between sleep disturbance, emotional well-being, or energy/fatigue at follow-up in those who were randomized to CaD supplementation compared to those taking the placebo. Conclusions: Our data suggest that supplementation with 1000 mg of calcium plus 400 IU of vitamin D does not influence menopause-related symptoms over an average of 5.7 years of follow-up among postmenopausal women with an average age of 64 at the WHI baseline visit.

Original languageEnglish (US)
Pages (from-to)377-383
Number of pages7
JournalMaturitas
Volume81
Issue number3
DOIs
StatePublished - Jul 1 2015

Fingerprint

Women's Health
Menopause
Vitamin D
Calcium
Placebos
Calcium Carbonate
Fatigue of materials
Fatigue
Sleep
Research

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Obstetrics and Gynecology

Cite this

LeBlanc, E. S., Hedlin, H., Qin, F., Desai, M., Wactawski-Wende, J., Perrin, N., ... Stefanick, M. L. (2015). Calcium and vitamin D supplementation do not influence menopause-related symptoms: Results of the Women's Health Initiative Trial. Maturitas, 81(3), 377-383. https://doi.org/10.1016/j.maturitas.2015.04.007

Calcium and vitamin D supplementation do not influence menopause-related symptoms : Results of the Women's Health Initiative Trial. / LeBlanc, Erin S.; Hedlin, Haley; Qin, Feifei; Desai, Manisha; Wactawski-Wende, Jean; Perrin, Nancy; Manson, Joann E.; Johnson, Karen; Masaki, Kamal; Tylavsky, Frances; Stefanick, Marcia L.

In: Maturitas, Vol. 81, No. 3, 01.07.2015, p. 377-383.

Research output: Contribution to journalArticle

LeBlanc, ES, Hedlin, H, Qin, F, Desai, M, Wactawski-Wende, J, Perrin, N, Manson, JE, Johnson, K, Masaki, K, Tylavsky, F & Stefanick, ML 2015, 'Calcium and vitamin D supplementation do not influence menopause-related symptoms: Results of the Women's Health Initiative Trial', Maturitas, vol. 81, no. 3, pp. 377-383. https://doi.org/10.1016/j.maturitas.2015.04.007
LeBlanc, Erin S. ; Hedlin, Haley ; Qin, Feifei ; Desai, Manisha ; Wactawski-Wende, Jean ; Perrin, Nancy ; Manson, Joann E. ; Johnson, Karen ; Masaki, Kamal ; Tylavsky, Frances ; Stefanick, Marcia L. / Calcium and vitamin D supplementation do not influence menopause-related symptoms : Results of the Women's Health Initiative Trial. In: Maturitas. 2015 ; Vol. 81, No. 3. pp. 377-383.
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