Calcium- and voltage-gated BK channels in vascular smooth muscle

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Ion channels in vascular smooth muscle regulate myogenic tone and vessel contractility. In particular, activation of calcium- and voltage-gated potassium channels of large conductance (BK channels) results in outward current that shifts the membrane potential toward more negative values, triggering a negative feed-back loop on depolarization-induced calcium influx and SM contraction. In this short review, we first present the molecular basis of vascular smooth muscle BK channels and the role of subunit composition and trafficking in the regulation of myogenic tone and vascular contractility. BK channel modulation by endogenous signaling molecules, and paracrine and endocrine mediators follows. Lastly, we describe the functional changes in smooth muscle BK channels that contribute to, or are triggered by, common physiological conditions and pathologies, including obesity, diabetes, and systemic hypertension.

Original languageEnglish (US)
Pages (from-to)1271-1289
Number of pages19
JournalPflugers Archiv European Journal of Physiology
Volume470
Issue number9
DOIs
StatePublished - Sep 1 2018

Fingerprint

Large-Conductance Calcium-Activated Potassium Channels
Vascular Smooth Muscle
Muscle
Calcium
Electric potential
Paracrine Communication
Voltage-Gated Potassium Channels
Depolarization
Pathology
Medical problems
Ion Channels
Membrane Potentials
Smooth Muscle
Blood Vessels
Obesity
Chemical activation
Modulation
Hypertension
Membranes
Feedback

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

Cite this

Calcium- and voltage-gated BK channels in vascular smooth muscle. / Dopico, Alejandro; Bukiya, Anna; Jaggar, Jonathan.

In: Pflugers Archiv European Journal of Physiology, Vol. 470, No. 9, 01.09.2018, p. 1271-1289.

Research output: Contribution to journalReview article

@article{5649cf1530804ae4bf68aadbbfb15809,
title = "Calcium- and voltage-gated BK channels in vascular smooth muscle",
abstract = "Ion channels in vascular smooth muscle regulate myogenic tone and vessel contractility. In particular, activation of calcium- and voltage-gated potassium channels of large conductance (BK channels) results in outward current that shifts the membrane potential toward more negative values, triggering a negative feed-back loop on depolarization-induced calcium influx and SM contraction. In this short review, we first present the molecular basis of vascular smooth muscle BK channels and the role of subunit composition and trafficking in the regulation of myogenic tone and vascular contractility. BK channel modulation by endogenous signaling molecules, and paracrine and endocrine mediators follows. Lastly, we describe the functional changes in smooth muscle BK channels that contribute to, or are triggered by, common physiological conditions and pathologies, including obesity, diabetes, and systemic hypertension.",
author = "Alejandro Dopico and Anna Bukiya and Jonathan Jaggar",
year = "2018",
month = "9",
day = "1",
doi = "10.1007/s00424-018-2151-y",
language = "English (US)",
volume = "470",
pages = "1271--1289",
journal = "Pflugers Archiv European Journal of Physiology",
issn = "0031-6768",
publisher = "Springer Verlag",
number = "9",

}

TY - JOUR

T1 - Calcium- and voltage-gated BK channels in vascular smooth muscle

AU - Dopico, Alejandro

AU - Bukiya, Anna

AU - Jaggar, Jonathan

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Ion channels in vascular smooth muscle regulate myogenic tone and vessel contractility. In particular, activation of calcium- and voltage-gated potassium channels of large conductance (BK channels) results in outward current that shifts the membrane potential toward more negative values, triggering a negative feed-back loop on depolarization-induced calcium influx and SM contraction. In this short review, we first present the molecular basis of vascular smooth muscle BK channels and the role of subunit composition and trafficking in the regulation of myogenic tone and vascular contractility. BK channel modulation by endogenous signaling molecules, and paracrine and endocrine mediators follows. Lastly, we describe the functional changes in smooth muscle BK channels that contribute to, or are triggered by, common physiological conditions and pathologies, including obesity, diabetes, and systemic hypertension.

AB - Ion channels in vascular smooth muscle regulate myogenic tone and vessel contractility. In particular, activation of calcium- and voltage-gated potassium channels of large conductance (BK channels) results in outward current that shifts the membrane potential toward more negative values, triggering a negative feed-back loop on depolarization-induced calcium influx and SM contraction. In this short review, we first present the molecular basis of vascular smooth muscle BK channels and the role of subunit composition and trafficking in the regulation of myogenic tone and vascular contractility. BK channel modulation by endogenous signaling molecules, and paracrine and endocrine mediators follows. Lastly, we describe the functional changes in smooth muscle BK channels that contribute to, or are triggered by, common physiological conditions and pathologies, including obesity, diabetes, and systemic hypertension.

UR - http://www.scopus.com/inward/record.url?scp=85046728673&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046728673&partnerID=8YFLogxK

U2 - 10.1007/s00424-018-2151-y

DO - 10.1007/s00424-018-2151-y

M3 - Review article

VL - 470

SP - 1271

EP - 1289

JO - Pflugers Archiv European Journal of Physiology

JF - Pflugers Archiv European Journal of Physiology

SN - 0031-6768

IS - 9

ER -