Calcium currents in retrogradely labeled pyramidal cells from rat sensorimotor cortex

Ansalan Stewart, Robert Foehring

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Our previous studies of calcium (Ca2+) currents in cortical pyramidal cells revealed that the percentage contribution of each Ca2+ current type to the whole cell Ca2+ current varies from cell to cell. The extent to which these currents are modulated by neurotransmitters is also variable. This study was directed at testing the hypothesis that a major source of this variability is recording from multiple populations of pyramidal cells. We used the whole cell patch-clamp technique to record from dissociated corticocortical, corticostriatal, and corticotectal projecting pyramidal cells. There were significant differences between the three pyramidal cell types in the mean percentage of L-, P-, and N-type Ca2+ currents. For both N- and P-type currents, the range of percentages expressed was small for corticostriatal and corticotectal cells as compared with cells which project to the corpus callosum or to the general population. The variance was significantly different between cell types for N-and P-type currents. These results suggest that an important source of the variability in the proportions of Ca2+ current types present in neocortical pyramidal neurons is recording from multiple populations of pyramidal cells.

Original languageEnglish (US)
Pages (from-to)2349-2354
Number of pages6
JournalJournal of Neurophysiology
Volume83
Issue number4
StatePublished - 2000

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Pyramidal Cells
Calcium
Population
Corpus Callosum
Patch-Clamp Techniques
Sensorimotor Cortex
Neurotransmitter Agents

All Science Journal Classification (ASJC) codes

  • Physiology
  • Neuroscience(all)

Cite this

Calcium currents in retrogradely labeled pyramidal cells from rat sensorimotor cortex. / Stewart, Ansalan; Foehring, Robert.

In: Journal of Neurophysiology, Vol. 83, No. 4, 2000, p. 2349-2354.

Research output: Contribution to journalArticle

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