Calcium Signals

STIM Dynamics Mediate Spatially Unique Oscillations

Salvatore Mancarella, Youjun Wang, Donald L. Gill

Research output: Contribution to journalShort survey

14 Citations (Scopus)

Abstract

Receptor-induced Ca2+ oscillations provide 'digitized' signals that confer precise activation of downstream targets. New studies reveal that STIM proteins - sensors of endoplasmic reticulum Ca2+ levels - cyclically translocate during oscillations, transiently coupling to activate cell-surface Ca2+ entry channels, resulting in a spatially unique signal that selectively triggers immediate-early gene expression.

Original languageEnglish (US)
JournalCurrent Biology
Volume19
Issue number20
DOIs
StatePublished - Nov 3 2009
Externally publishedYes

Fingerprint

Immediate-Early Genes
Gene expression
Endoplasmic Reticulum
oscillation
Chemical activation
Calcium
Gene Expression
calcium
Sensors
Proteins
endoplasmic reticulum
gene expression
receptors
proteins
cells

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Calcium Signals : STIM Dynamics Mediate Spatially Unique Oscillations. / Mancarella, Salvatore; Wang, Youjun; Gill, Donald L.

In: Current Biology, Vol. 19, No. 20, 03.11.2009.

Research output: Contribution to journalShort survey

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