Calcium supplementation in mild preeclampsia remote from term

A randomized double-blind clinical trial

Luis Sanchez-Ramos, Charles Adair, Andrew M. Kaunitz, Donna K. Briones, Gerardo O. Del Valle, Isaac Delke

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: To determine whether calcium supplementation prevents progression to severe disease in preterm nulliparous women with mild preeclampsia. Methods: Seventy-five women hospitalized at 24-36 weeks' gestation because of mild preeclampsia were randomized to receive either 2 g/day of elemental calcium (36 women) or placebo (39). Both groups had similar demographic characteristics, initial blood pressure measurements, and amount of proteinuria. Diagnostic criteria and clinical management for severe preeclampsia were applied consistently. Results: Eighteen of 36 calcium-treated subjects (50%, 95% confidence interval [CI] 33-67) developed severe preeclampsia, compared with 19 of 39 (48.7%, 95% CI 32-65) in the placebo group (relative risk 1.03, 95% CI 0.64-1.03; P = 1.00). Blood pressure values, gestational age at delivery, newborn weights, incidence of low Apgar scores, and umbilical arterial blood gases were similar for the two groups. Conclusion: Calcium supplementation does not prevent severe preeclampsia in preterm patients with mild disease.

Original languageEnglish (US)
Pages (from-to)915-918
Number of pages4
JournalObstetrics and Gynecology
Volume85
Issue number6
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

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Pre-Eclampsia
Clinical Trials
Calcium
Confidence Intervals
Placebos
Blood Pressure
Umbilicus
Apgar Score
Proteinuria
Gestational Age
Gases
Demography
Newborn Infant
Weights and Measures
Pregnancy
Incidence

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Calcium supplementation in mild preeclampsia remote from term : A randomized double-blind clinical trial. / Sanchez-Ramos, Luis; Adair, Charles; Kaunitz, Andrew M.; Briones, Donna K.; Del Valle, Gerardo O.; Delke, Isaac.

In: Obstetrics and Gynecology, Vol. 85, No. 6, 01.01.1995, p. 915-918.

Research output: Contribution to journalArticle

Sanchez-Ramos, Luis ; Adair, Charles ; Kaunitz, Andrew M. ; Briones, Donna K. ; Del Valle, Gerardo O. ; Delke, Isaac. / Calcium supplementation in mild preeclampsia remote from term : A randomized double-blind clinical trial. In: Obstetrics and Gynecology. 1995 ; Vol. 85, No. 6. pp. 915-918.
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