Calcium/vitamin D supplementation and cardiovascular events

Judith Hsia, Gerardo Heiss, Hong Ren, Matthew Allison, Nancy C. Dolan, Philip Greenland, Susan R. Heckbert, Karen Johnson, Joann E. Manson, Stephen Sidney, Maurizio Trevisan

Research output: Contribution to journalArticle

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Abstract

BACKGROUND - Individuals with vascular or valvular calcification are at increased risk for coronary events, but the relationship between calcium consumption and cardiovascular events is uncertain. We evaluated the risk of coronary and cerebrovascular events in the Women's Health Initiative randomized trial of calcium plus vitamin D supplementation. METHODS AND RESULTS - We randomized 36 282 postmenopausal women 50 to 79 years of age at 40 clinical sites to calcium carbonate 500 mg with vitamin D 200 IU twice daily or to placebo. Cardiovascular disease was a prespecified secondary efficacy outcome. During 7 years of follow-up, myocardial infarction or coronary heart disease death was confirmed for 499 women assigned to calcium/vitamin D and 475 women assigned to placebo (hazard ratio, 1.04; 95% confidence interval, 0.92 to 1.18). Stroke was confirmed among 362 women assigned to calcium/vitamin D and 377 assigned to placebo (hazard ratio, 0.95; 95% confidence interval, 0.82 to 1.10). In subgroup analyses, women with higher total calcium intake (diet plus supplements) at baseline were not at higher risk for coronary events (P=0.91 for interaction) or stroke (P=0.14 for interaction) if assigned to active calcium/vitamin D. CONCLUSIONS - Calcium/vitamin D supplementation neither increased nor decreased coronary or cerebrovascular risk in generally healthy postmenopausal women over a 7-year use period.

Original languageEnglish (US)
Pages (from-to)846-854
Number of pages9
JournalCirculation
Volume115
Issue number7
DOIs
StatePublished - Feb 1 2007

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Vitamin D
Calcium
Placebos
Stroke
Confidence Intervals
Calcium Carbonate
Women's Health
Coronary Disease
Blood Vessels
Cardiovascular Diseases
Myocardial Infarction
Diet

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Hsia, J., Heiss, G., Ren, H., Allison, M., Dolan, N. C., Greenland, P., ... Trevisan, M. (2007). Calcium/vitamin D supplementation and cardiovascular events. Circulation, 115(7), 846-854. https://doi.org/10.1161/CIRCULATIONAHA.106.673491

Calcium/vitamin D supplementation and cardiovascular events. / Hsia, Judith; Heiss, Gerardo; Ren, Hong; Allison, Matthew; Dolan, Nancy C.; Greenland, Philip; Heckbert, Susan R.; Johnson, Karen; Manson, Joann E.; Sidney, Stephen; Trevisan, Maurizio.

In: Circulation, Vol. 115, No. 7, 01.02.2007, p. 846-854.

Research output: Contribution to journalArticle

Hsia, J, Heiss, G, Ren, H, Allison, M, Dolan, NC, Greenland, P, Heckbert, SR, Johnson, K, Manson, JE, Sidney, S & Trevisan, M 2007, 'Calcium/vitamin D supplementation and cardiovascular events', Circulation, vol. 115, no. 7, pp. 846-854. https://doi.org/10.1161/CIRCULATIONAHA.106.673491
Hsia J, Heiss G, Ren H, Allison M, Dolan NC, Greenland P et al. Calcium/vitamin D supplementation and cardiovascular events. Circulation. 2007 Feb 1;115(7):846-854. https://doi.org/10.1161/CIRCULATIONAHA.106.673491
Hsia, Judith ; Heiss, Gerardo ; Ren, Hong ; Allison, Matthew ; Dolan, Nancy C. ; Greenland, Philip ; Heckbert, Susan R. ; Johnson, Karen ; Manson, Joann E. ; Sidney, Stephen ; Trevisan, Maurizio. / Calcium/vitamin D supplementation and cardiovascular events. In: Circulation. 2007 ; Vol. 115, No. 7. pp. 846-854.
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AB - BACKGROUND - Individuals with vascular or valvular calcification are at increased risk for coronary events, but the relationship between calcium consumption and cardiovascular events is uncertain. We evaluated the risk of coronary and cerebrovascular events in the Women's Health Initiative randomized trial of calcium plus vitamin D supplementation. METHODS AND RESULTS - We randomized 36 282 postmenopausal women 50 to 79 years of age at 40 clinical sites to calcium carbonate 500 mg with vitamin D 200 IU twice daily or to placebo. Cardiovascular disease was a prespecified secondary efficacy outcome. During 7 years of follow-up, myocardial infarction or coronary heart disease death was confirmed for 499 women assigned to calcium/vitamin D and 475 women assigned to placebo (hazard ratio, 1.04; 95% confidence interval, 0.92 to 1.18). Stroke was confirmed among 362 women assigned to calcium/vitamin D and 377 assigned to placebo (hazard ratio, 0.95; 95% confidence interval, 0.82 to 1.10). In subgroup analyses, women with higher total calcium intake (diet plus supplements) at baseline were not at higher risk for coronary events (P=0.91 for interaction) or stroke (P=0.14 for interaction) if assigned to active calcium/vitamin D. CONCLUSIONS - Calcium/vitamin D supplementation neither increased nor decreased coronary or cerebrovascular risk in generally healthy postmenopausal women over a 7-year use period.

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