Can we induce tolerance in rheumatoid arthritis?

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Oral tolerance (OT) has worked well in numerous laboratory animal models of autoimmune diseases. Humans have been orally tolerized to keyhole limpet hemocyanin (KLH); patients with systemic sclerosis (SSc, scleroderma) have been orally tolerized to oral type I collagen (CI). However, clinical trials of oral type II collagen (CII) therapy in rheumatoid arthritis (RA) have had mixed results. Clinical studies show that compounds (such as nonsteroidal antiinflammatory drugs and prednisone) that inhibit generation of PGE(2) block OT induction. In murine OT models, the PGE(1) analog, misoprostol, reverses the NSAID OT block. These animal studies suggest that OT to CII or other antigens in patients with RA should be inducible if measures are taken to maintain normal prostaglandin function in the gut- associated lymphoid tissue (GALT). A clinical trial is underway in patients with RA to assess whether withholding NSAIDs and prednisone will allow OT to to be induced, and whether oral CII has meaningful clinical efficacy in this disease.

Original languageEnglish (US)
Pages (from-to)64-69
Number of pages6
JournalCurrent Rheumatology Reports
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2001

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Rheumatoid Arthritis
Non-Steroidal Anti-Inflammatory Agents
Prednisone
Prostaglandins E
Clinical Trials
Misoprostol
Collagen Type II
Systemic Scleroderma
Lymphoid Tissue
Collagen Type I
Autoimmune Diseases
Prostaglandins
Anti-Inflammatory Agents
Animal Models
Antigens
Pharmaceutical Preparations
Therapeutics
Clinical Studies
keyhole-limpet hemocyanin

All Science Journal Classification (ASJC) codes

  • Rheumatology

Cite this

Can we induce tolerance in rheumatoid arthritis? / Postlethwaite, Arnold.

In: Current Rheumatology Reports, Vol. 3, No. 1, 01.01.2001, p. 64-69.

Research output: Contribution to journalReview article

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