Candida sepsis and association with retinopathy of prematurity

Madhur Mittal, Ramasubbareddy Dhanireddy, Rosemary D. Higgins

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Objective. To assess the association of Candida sepsis with retinopathy of prematurity (ROP) in extremely low birth weight infants. Methods. We prospectively identified 253 infants admitted to the Critical Care Nursery at Georgetown University Hospital with birth weights ≤1000 g born between January 1, 1994, and June 30, 1996. Of these 253 infants, 62 died and 55 were transferred to other institutions before ophthalmologic screening for ROP. Clinical data on 98% (133/136) infants were reviewed. Candida sepsis was defined as a positive blood culture for Candida species. Severity of ROP was staged by the International Classification for ROP. Data were analyzed using the χ2 test for nominal data, unpaired t test for continuous data, Mann- Whitney U test for ordinal data, and logistic regression. Results. The mean birth weight (±SD) of the population studied was 777 g (±136 g), and the mean gestational age at birth was 26.0 weeks (±1.8 weeks). The overall incidence of ROP was 74%, and it correlated significantly with birth weight, gestational age, days on supplemental oxygen, and 5-minute Apgar scores. The incidence of ROP was significantly higher in the infants who had Candida sepsis (21/22 [95%]) compared with those who did not (77/111 [69%]). Using logistic regression to control for the influence of birth weight, gestational age, days on supplemental oxygen, and 5-minute Apgar scores, Candida sepsis was an independent predictor of stage 3 or worse ROP. In addition, 9 (41%) of 22 infants with Candida sepsis required laser surgery compared with 10 (9%) of 111 infants without Candida sepsis. This difference was significant independent of birth weight, gestational age, days on supplemental oxygen, and 5-minute Apgar scores. Conclusions. Candida sepsis is independently associated with increased severity of ROP and the need for laser surgery in extremely low birth weight infants.

Original languageEnglish (US)
Pages (from-to)654-657
Number of pages4
JournalPediatrics
Volume101
Issue number4 I
DOIs
StatePublished - Apr 1 1998
Externally publishedYes

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Retinopathy of Prematurity
Candida
Sepsis
Birth Weight
Gestational Age
Apgar Score
Extremely Low Birth Weight Infant
Laser Therapy
Oxygen
Logistic Models
Nurseries
Incidence
Critical Care
Nonparametric Statistics
Parturition

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Candida sepsis and association with retinopathy of prematurity. / Mittal, Madhur; Dhanireddy, Ramasubbareddy; Higgins, Rosemary D.

In: Pediatrics, Vol. 101, No. 4 I, 01.04.1998, p. 654-657.

Research output: Contribution to journalArticle

Mittal, Madhur ; Dhanireddy, Ramasubbareddy ; Higgins, Rosemary D. / Candida sepsis and association with retinopathy of prematurity. In: Pediatrics. 1998 ; Vol. 101, No. 4 I. pp. 654-657.
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abstract = "Objective. To assess the association of Candida sepsis with retinopathy of prematurity (ROP) in extremely low birth weight infants. Methods. We prospectively identified 253 infants admitted to the Critical Care Nursery at Georgetown University Hospital with birth weights ≤1000 g born between January 1, 1994, and June 30, 1996. Of these 253 infants, 62 died and 55 were transferred to other institutions before ophthalmologic screening for ROP. Clinical data on 98{\%} (133/136) infants were reviewed. Candida sepsis was defined as a positive blood culture for Candida species. Severity of ROP was staged by the International Classification for ROP. Data were analyzed using the χ2 test for nominal data, unpaired t test for continuous data, Mann- Whitney U test for ordinal data, and logistic regression. Results. The mean birth weight (±SD) of the population studied was 777 g (±136 g), and the mean gestational age at birth was 26.0 weeks (±1.8 weeks). The overall incidence of ROP was 74{\%}, and it correlated significantly with birth weight, gestational age, days on supplemental oxygen, and 5-minute Apgar scores. The incidence of ROP was significantly higher in the infants who had Candida sepsis (21/22 [95{\%}]) compared with those who did not (77/111 [69{\%}]). Using logistic regression to control for the influence of birth weight, gestational age, days on supplemental oxygen, and 5-minute Apgar scores, Candida sepsis was an independent predictor of stage 3 or worse ROP. In addition, 9 (41{\%}) of 22 infants with Candida sepsis required laser surgery compared with 10 (9{\%}) of 111 infants without Candida sepsis. This difference was significant independent of birth weight, gestational age, days on supplemental oxygen, and 5-minute Apgar scores. Conclusions. Candida sepsis is independently associated with increased severity of ROP and the need for laser surgery in extremely low birth weight infants.",
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AB - Objective. To assess the association of Candida sepsis with retinopathy of prematurity (ROP) in extremely low birth weight infants. Methods. We prospectively identified 253 infants admitted to the Critical Care Nursery at Georgetown University Hospital with birth weights ≤1000 g born between January 1, 1994, and June 30, 1996. Of these 253 infants, 62 died and 55 were transferred to other institutions before ophthalmologic screening for ROP. Clinical data on 98% (133/136) infants were reviewed. Candida sepsis was defined as a positive blood culture for Candida species. Severity of ROP was staged by the International Classification for ROP. Data were analyzed using the χ2 test for nominal data, unpaired t test for continuous data, Mann- Whitney U test for ordinal data, and logistic regression. Results. The mean birth weight (±SD) of the population studied was 777 g (±136 g), and the mean gestational age at birth was 26.0 weeks (±1.8 weeks). The overall incidence of ROP was 74%, and it correlated significantly with birth weight, gestational age, days on supplemental oxygen, and 5-minute Apgar scores. The incidence of ROP was significantly higher in the infants who had Candida sepsis (21/22 [95%]) compared with those who did not (77/111 [69%]). Using logistic regression to control for the influence of birth weight, gestational age, days on supplemental oxygen, and 5-minute Apgar scores, Candida sepsis was an independent predictor of stage 3 or worse ROP. In addition, 9 (41%) of 22 infants with Candida sepsis required laser surgery compared with 10 (9%) of 111 infants without Candida sepsis. This difference was significant independent of birth weight, gestational age, days on supplemental oxygen, and 5-minute Apgar scores. Conclusions. Candida sepsis is independently associated with increased severity of ROP and the need for laser surgery in extremely low birth weight infants.

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