Candida sp. isolated from bronchoalveolar lavage: Clinical significance in critically ill trauma patients

G Christopher Wood, Eric W. Mueller, Martin Croce, Bradley Boucher, Timothy Fabian

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Objective: Based on limited data, Candida sp. isolates from bronchoalveolar lavage (BAL) cultures in immunocompetent patients are thought to be contaminants rather than pathogens. The objective of this study was to determine the clinical significance of Candida sp. isolated from BAL cultures in critically ill trauma patients. Design and setting: Retrospective study in a level 1 trauma intensive care unit. Patients and participants: All patients with Candida sp. isolated from BAL cultures over a 3-year period; 85 Candida positive BAL cultures from 62 patients were studied. Measurements and results: The primary outcomes were the incidence of Candida sp. in BAL, antifungal use, course of the possible infection, and mortality. Of 1077 BAL cultures 85 (8%) grew Candida sp., representing 64 episodes of possible Candida sp. ventilator-associated pneumonia. No colony counts exceeded the diagnostic threshold for bacterial VAP (≥ 105 cfu/ml). Only 2 of 64 episodes (3%) were treated with systemic antifungals. Three other episodes (5%) were treated because of concomitant therapy for Candida sp. at other sites. The majority of episodes were not treated with antifungals and were considered contaminants (59/64, 92%). No patients developed subsequent candidemia, and most follow-up BALs (74%) were negative for Candida sp. Overall mortality (17%) was similar to previous patients with similar severity of injury at the study center (18%). Conclusions: The results of this study suggest that isolation of Candida sp. from BAL in quantities below the diagnostic threshold for VAP in this population does not require antifungal therapy.

Original languageEnglish (US)
Pages (from-to)599-603
Number of pages5
JournalIntensive care medicine
Volume32
Issue number4
DOIs
StatePublished - Apr 1 2006

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Bronchoalveolar Lavage
Candida
Critical Illness
Wounds and Injuries
Candidemia
Ventilator-Associated Pneumonia
Dimercaprol
Mortality
Intensive Care Units
Retrospective Studies
Incidence

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine

Cite this

Candida sp. isolated from bronchoalveolar lavage : Clinical significance in critically ill trauma patients. / Wood, G Christopher; Mueller, Eric W.; Croce, Martin; Boucher, Bradley; Fabian, Timothy.

In: Intensive care medicine, Vol. 32, No. 4, 01.04.2006, p. 599-603.

Research output: Contribution to journalArticle

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abstract = "Objective: Based on limited data, Candida sp. isolates from bronchoalveolar lavage (BAL) cultures in immunocompetent patients are thought to be contaminants rather than pathogens. The objective of this study was to determine the clinical significance of Candida sp. isolated from BAL cultures in critically ill trauma patients. Design and setting: Retrospective study in a level 1 trauma intensive care unit. Patients and participants: All patients with Candida sp. isolated from BAL cultures over a 3-year period; 85 Candida positive BAL cultures from 62 patients were studied. Measurements and results: The primary outcomes were the incidence of Candida sp. in BAL, antifungal use, course of the possible infection, and mortality. Of 1077 BAL cultures 85 (8{\%}) grew Candida sp., representing 64 episodes of possible Candida sp. ventilator-associated pneumonia. No colony counts exceeded the diagnostic threshold for bacterial VAP (≥ 105 cfu/ml). Only 2 of 64 episodes (3{\%}) were treated with systemic antifungals. Three other episodes (5{\%}) were treated because of concomitant therapy for Candida sp. at other sites. The majority of episodes were not treated with antifungals and were considered contaminants (59/64, 92{\%}). No patients developed subsequent candidemia, and most follow-up BALs (74{\%}) were negative for Candida sp. Overall mortality (17{\%}) was similar to previous patients with similar severity of injury at the study center (18{\%}). Conclusions: The results of this study suggest that isolation of Candida sp. from BAL in quantities below the diagnostic threshold for VAP in this population does not require antifungal therapy.",
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