Candidal meningitis in children with cancer

Jonathan Mccullers, Sergio L. Vargas, Patricia M. Flynn, Bassem I. Razzouk, Jerry L. Shenep

Research output: Contribution to journalArticle

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Abstract

Candidal meningitis is a rare disease that is seen most frequently in neonates, neurosurgical patients, and the immunocompromised host. We describe a series of 12 children with cancer (all of whom had leukemia) who had candidal meningitis develop. Univariate analysis revealed that duration of fever, antibiotic therapy, and profound neutropenia and use of total parenteral nutrition were significantly associated (P < .05) with candidal meningitis in children with cancer, compared with matched control subjects. Only duration of profound neutropenia (P = .08) and use of total parenteral nutrition (P = .06) approached significance in the multivariate analysis. One species of Candida, Candida tropicalis, was responsible for 11 of the 12 cases, indicating increased pathogenicity of this organism in CNS disease. The cases were invariably fatal, supporting aggressive treatment of candidal meningitis in immunocompromised patients and further study of the prevention, diagnosis, and management of C. tropicalis meningitis.

Original languageEnglish (US)
Pages (from-to)451-457
Number of pages7
JournalClinical Infectious Diseases
Volume31
Issue number2
DOIs
StatePublished - Jan 1 2000

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Meningitis
Candida tropicalis
Total Parenteral Nutrition
Immunocompromised Host
Neoplasms
Neutropenia
Induced Hyperthermia
Central Nervous System Diseases
Rare Diseases
Candida
Virulence
Leukemia
Multivariate Analysis
Newborn Infant
Anti-Bacterial Agents
Therapeutics

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Mccullers, J., Vargas, S. L., Flynn, P. M., Razzouk, B. I., & Shenep, J. L. (2000). Candidal meningitis in children with cancer. Clinical Infectious Diseases, 31(2), 451-457. https://doi.org/10.1086/313987

Candidal meningitis in children with cancer. / Mccullers, Jonathan; Vargas, Sergio L.; Flynn, Patricia M.; Razzouk, Bassem I.; Shenep, Jerry L.

In: Clinical Infectious Diseases, Vol. 31, No. 2, 01.01.2000, p. 451-457.

Research output: Contribution to journalArticle

Mccullers, J, Vargas, SL, Flynn, PM, Razzouk, BI & Shenep, JL 2000, 'Candidal meningitis in children with cancer', Clinical Infectious Diseases, vol. 31, no. 2, pp. 451-457. https://doi.org/10.1086/313987
Mccullers J, Vargas SL, Flynn PM, Razzouk BI, Shenep JL. Candidal meningitis in children with cancer. Clinical Infectious Diseases. 2000 Jan 1;31(2):451-457. https://doi.org/10.1086/313987
Mccullers, Jonathan ; Vargas, Sergio L. ; Flynn, Patricia M. ; Razzouk, Bassem I. ; Shenep, Jerry L. / Candidal meningitis in children with cancer. In: Clinical Infectious Diseases. 2000 ; Vol. 31, No. 2. pp. 451-457.
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