Candidate gene association study of bmi-related loci, weight, and adiposity in old age

Rachel A. Murphy, Michael A. Nalls, Margaux Keller, Melissa Garcia, Stephen B. Kritchevsky, Frances Tylavsky, Anne B. Newman, Gregory J. Tranah, Gudny Eiriksdottir, Vilmundur Gudnason, Tamara B. Harris

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Most genome-wide association studies are confined to middle-Aged populations. It is unclear whether associations between single nucleotide polymorphisms (SNPs) and obesity persist in old age. We aimed to relate 10 body mass index (BMI)-Associated SNPs to weight, BMI, % fat, visceral and subcutaneous adipose tissue in Health ABC and AGES-Reykjavik comprising 4,846 individuals of European Ancestry, and 1,139 African Americans over age 65. SNPs were scaled using effect estimates from candidate SNPs. In Health ABC, a SNP near GNPDA2 was modestly associated with weight and SAT area (p =. 008, p =. 001). Risk score (sum of scaled SNPs) was associated with weight, BMI, and SAT area (p <. 0001 for all), but neither GNPDA2 nor risk score was associated with weight, BMI, visceral adippose tissue, subcutaneous adipose tissue, or % fat in AGES-Reykjavik. In African Americans, a SNP near SEC16B was weakly associated with weight (p =. 04). In this sample of older adults, no BMI-Associated SNPs were associated with weight or adiposity.

Original languageEnglish (US)
Pages (from-to)661-666
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume68
Issue number6
DOIs
StatePublished - Jun 1 2013

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Adiposity
Genetic Association Studies
Single Nucleotide Polymorphism
Weights and Measures
Body Mass Index
Subcutaneous Fat
African Americans
Fats
Intra-Abdominal Fat
Genome-Wide Association Study
Health
Obesity
Population

All Science Journal Classification (ASJC) codes

  • Aging
  • Geriatrics and Gerontology

Cite this

Candidate gene association study of bmi-related loci, weight, and adiposity in old age. / Murphy, Rachel A.; Nalls, Michael A.; Keller, Margaux; Garcia, Melissa; Kritchevsky, Stephen B.; Tylavsky, Frances; Newman, Anne B.; Tranah, Gregory J.; Eiriksdottir, Gudny; Gudnason, Vilmundur; Harris, Tamara B.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 68, No. 6, 01.06.2013, p. 661-666.

Research output: Contribution to journalArticle

Murphy, RA, Nalls, MA, Keller, M, Garcia, M, Kritchevsky, SB, Tylavsky, F, Newman, AB, Tranah, GJ, Eiriksdottir, G, Gudnason, V & Harris, TB 2013, 'Candidate gene association study of bmi-related loci, weight, and adiposity in old age', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 68, no. 6, pp. 661-666. https://doi.org/10.1093/gerona/gls227
Murphy, Rachel A. ; Nalls, Michael A. ; Keller, Margaux ; Garcia, Melissa ; Kritchevsky, Stephen B. ; Tylavsky, Frances ; Newman, Anne B. ; Tranah, Gregory J. ; Eiriksdottir, Gudny ; Gudnason, Vilmundur ; Harris, Tamara B. / Candidate gene association study of bmi-related loci, weight, and adiposity in old age. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2013 ; Vol. 68, No. 6. pp. 661-666.
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