Carbonylation of dialkylcyanocuprates with carbon monoxide

Synthesis of α-hydroxyketones

George Kabalka, Nan Sheng Li, Su Yu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Dialkylcyanocuprates, prepared from copper(I) cyanide and the corresponding alkyllithium or Gringard reagents, readily react with carbon monoxide in the presence of tri-n-butylphosphine at -78°C in THF to give α-hydroxyketones in high yields (65-85%).

Original languageEnglish (US)
Pages (from-to)2203-2206
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number13
DOIs
StatePublished - Mar 31 1997
Externally publishedYes

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Carbonylation
Cyanides
Carbon Monoxide
Copper
tri-n-butylphosphine

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Carbonylation of dialkylcyanocuprates with carbon monoxide : Synthesis of α-hydroxyketones. / Kabalka, George; Li, Nan Sheng; Yu, Su.

In: Tetrahedron Letters, Vol. 38, No. 13, 31.03.1997, p. 2203-2206.

Research output: Contribution to journalArticle

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