Carcinosarcoma of the uterus associated with a nongestational choriocarcinoma

Hanh M. Khuu, Carol P. Crisco, Larry Kilgore, William H. Rodgers, Michael G. Conner

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Choriocarcinoma has been reported in association with endometrial carcinoma and as a metaplastic change in multiple carcinomas, including liver, urinary bladder, lung, and the gastrointestinal tract. We report choriocarcinoma in conjunction with a carcinosarcoma (also called malignant mullerian mixed tumor) in a 71-year-old woman whose hysterectomy specimen revealed two polypoid lesions of the endometrium, one arising from the anterior endometrium and one arising from the posterior endometrium. Histologic examination revealed three histologic patterns. The anterior endometrial lesion showed a FIGO grade 2 endometrioid endometrial adenocarcinoma. The posterior endometrial lesion showed a carcinosarcoma composed of a high-grade adenocarcinoma and scant homologous stromal sarcoma. In addition, a choriocarcinoma was identified intermixed with the adenocarcinoma. The syncytiocytotrophoblasts and cytotrophoblasts stained strongly with β human chorionic gonadotropin (β-hCG) and human placental lactogen (hPL). The patient's β-hCG levels on postoperative days 14, 27, and 42 were 283, 32, and 7 mIU/mL, respectively. This unusual case suggests the importance of identifying the choriocarcinomatous component, since the serum β-hCG can serve as a marker of tumor recurrence postoperatively.

Original languageEnglish (US)
Pages (from-to)226-228
Number of pages3
JournalSouthern medical journal
Volume93
Issue number2
StatePublished - Feb 1 2000

Fingerprint

Non-gestational Choriocarcinoma
Carcinosarcoma
Choriocarcinoma
Endometrium
Uterus
Mullerian Mixed Tumor
Adenocarcinoma
Malignant Mixed Tumor
Endometrioid Carcinoma
Placental Lactogen
Trophoblasts
Chorionic Gonadotropin
Endometrial Neoplasms
Tumor Biomarkers
Hysterectomy
Sarcoma
Gastrointestinal Tract
Urinary Bladder
Carcinoma
Recurrence

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Khuu, H. M., Crisco, C. P., Kilgore, L., Rodgers, W. H., & Conner, M. G. (2000). Carcinosarcoma of the uterus associated with a nongestational choriocarcinoma. Southern medical journal, 93(2), 226-228.

Carcinosarcoma of the uterus associated with a nongestational choriocarcinoma. / Khuu, Hanh M.; Crisco, Carol P.; Kilgore, Larry; Rodgers, William H.; Conner, Michael G.

In: Southern medical journal, Vol. 93, No. 2, 01.02.2000, p. 226-228.

Research output: Contribution to journalArticle

Khuu, HM, Crisco, CP, Kilgore, L, Rodgers, WH & Conner, MG 2000, 'Carcinosarcoma of the uterus associated with a nongestational choriocarcinoma', Southern medical journal, vol. 93, no. 2, pp. 226-228.
Khuu, Hanh M. ; Crisco, Carol P. ; Kilgore, Larry ; Rodgers, William H. ; Conner, Michael G. / Carcinosarcoma of the uterus associated with a nongestational choriocarcinoma. In: Southern medical journal. 2000 ; Vol. 93, No. 2. pp. 226-228.
@article{79084ff3430640a1bf0a8b510e2816dd,
title = "Carcinosarcoma of the uterus associated with a nongestational choriocarcinoma",
abstract = "Choriocarcinoma has been reported in association with endometrial carcinoma and as a metaplastic change in multiple carcinomas, including liver, urinary bladder, lung, and the gastrointestinal tract. We report choriocarcinoma in conjunction with a carcinosarcoma (also called malignant mullerian mixed tumor) in a 71-year-old woman whose hysterectomy specimen revealed two polypoid lesions of the endometrium, one arising from the anterior endometrium and one arising from the posterior endometrium. Histologic examination revealed three histologic patterns. The anterior endometrial lesion showed a FIGO grade 2 endometrioid endometrial adenocarcinoma. The posterior endometrial lesion showed a carcinosarcoma composed of a high-grade adenocarcinoma and scant homologous stromal sarcoma. In addition, a choriocarcinoma was identified intermixed with the adenocarcinoma. The syncytiocytotrophoblasts and cytotrophoblasts stained strongly with β human chorionic gonadotropin (β-hCG) and human placental lactogen (hPL). The patient's β-hCG levels on postoperative days 14, 27, and 42 were 283, 32, and 7 mIU/mL, respectively. This unusual case suggests the importance of identifying the choriocarcinomatous component, since the serum β-hCG can serve as a marker of tumor recurrence postoperatively.",
author = "Khuu, {Hanh M.} and Crisco, {Carol P.} and Larry Kilgore and Rodgers, {William H.} and Conner, {Michael G.}",
year = "2000",
month = "2",
day = "1",
language = "English (US)",
volume = "93",
pages = "226--228",
journal = "Southern Medical Journal",
issn = "0038-4348",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Carcinosarcoma of the uterus associated with a nongestational choriocarcinoma

AU - Khuu, Hanh M.

AU - Crisco, Carol P.

AU - Kilgore, Larry

AU - Rodgers, William H.

AU - Conner, Michael G.

PY - 2000/2/1

Y1 - 2000/2/1

N2 - Choriocarcinoma has been reported in association with endometrial carcinoma and as a metaplastic change in multiple carcinomas, including liver, urinary bladder, lung, and the gastrointestinal tract. We report choriocarcinoma in conjunction with a carcinosarcoma (also called malignant mullerian mixed tumor) in a 71-year-old woman whose hysterectomy specimen revealed two polypoid lesions of the endometrium, one arising from the anterior endometrium and one arising from the posterior endometrium. Histologic examination revealed three histologic patterns. The anterior endometrial lesion showed a FIGO grade 2 endometrioid endometrial adenocarcinoma. The posterior endometrial lesion showed a carcinosarcoma composed of a high-grade adenocarcinoma and scant homologous stromal sarcoma. In addition, a choriocarcinoma was identified intermixed with the adenocarcinoma. The syncytiocytotrophoblasts and cytotrophoblasts stained strongly with β human chorionic gonadotropin (β-hCG) and human placental lactogen (hPL). The patient's β-hCG levels on postoperative days 14, 27, and 42 were 283, 32, and 7 mIU/mL, respectively. This unusual case suggests the importance of identifying the choriocarcinomatous component, since the serum β-hCG can serve as a marker of tumor recurrence postoperatively.

AB - Choriocarcinoma has been reported in association with endometrial carcinoma and as a metaplastic change in multiple carcinomas, including liver, urinary bladder, lung, and the gastrointestinal tract. We report choriocarcinoma in conjunction with a carcinosarcoma (also called malignant mullerian mixed tumor) in a 71-year-old woman whose hysterectomy specimen revealed two polypoid lesions of the endometrium, one arising from the anterior endometrium and one arising from the posterior endometrium. Histologic examination revealed three histologic patterns. The anterior endometrial lesion showed a FIGO grade 2 endometrioid endometrial adenocarcinoma. The posterior endometrial lesion showed a carcinosarcoma composed of a high-grade adenocarcinoma and scant homologous stromal sarcoma. In addition, a choriocarcinoma was identified intermixed with the adenocarcinoma. The syncytiocytotrophoblasts and cytotrophoblasts stained strongly with β human chorionic gonadotropin (β-hCG) and human placental lactogen (hPL). The patient's β-hCG levels on postoperative days 14, 27, and 42 were 283, 32, and 7 mIU/mL, respectively. This unusual case suggests the importance of identifying the choriocarcinomatous component, since the serum β-hCG can serve as a marker of tumor recurrence postoperatively.

UR - http://www.scopus.com/inward/record.url?scp=0033982044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033982044&partnerID=8YFLogxK

M3 - Article

C2 - 10701796

AN - SCOPUS:0033982044

VL - 93

SP - 226

EP - 228

JO - Southern Medical Journal

JF - Southern Medical Journal

SN - 0038-4348

IS - 2

ER -