Cardiac Dys-synchronization and arrhythmia in hyperhomocysteinemia

Karni S. Moshal, Clacy K. Camel, Ganesh K. Kartha, Mesia M. Steed, Neetu Tyagi, Utpal Sen, Yujian Kang, David Lominadze, Claudio Maldonado, Suresh C. Tyagi

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Although cardiac synchronization is important in maintaining myocardial performance, the mechanism of dys-synchronization in ailing to failing myocardium is unclear. It is known that the cardiac myocyte contracts and relaxes individually; however, it synchronizes only when connected to one another by low resistance communications called gap junction protein (connexins) and extra cellular matrix (ECM). Therefore, the remodeling of connexins and ECM in heart failure plays an important role in cardiac conduction, synchronization and arrhythmias. This review for the first time addresses the role of systemic accumulation of homocysteine (Hcy) in vasospasm, pressure and volume overload heart failure, hypertension and cardiac arrhythmias. The attenuation of calcium-dependent mitochondrial (mt), endothelial and neuronal nitric oxide synthase (mtNOS, eNOS and nNOS) by Hcy plays a significant role in cardiac arrhythmias. The signal transduction mechanisms in Hcy-induced matrix metalloproteinase (MMP) activation in cardiac connexin remodeling are discussed.

Original languageEnglish (US)
Pages (from-to)289-294
Number of pages6
JournalCurrent Neurovascular Research
Volume4
Issue number4
DOIs
StatePublished - Nov 1 2007

Fingerprint

Hyperhomocysteinemia
Connexins
Cardiac Arrhythmias
Homocysteine
Heart Failure
Nitric Oxide Synthase Type I
Nitric Oxide Synthase Type III
Matrix Metalloproteinases
Cardiac Myocytes
Signal Transduction
Myocardium
Hypertension
Calcium
Pressure

All Science Journal Classification (ASJC) codes

  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Moshal, K. S., Camel, C. K., Kartha, G. K., Steed, M. M., Tyagi, N., Sen, U., ... Tyagi, S. C. (2007). Cardiac Dys-synchronization and arrhythmia in hyperhomocysteinemia. Current Neurovascular Research, 4(4), 289-294. https://doi.org/10.2174/156720207782446324

Cardiac Dys-synchronization and arrhythmia in hyperhomocysteinemia. / Moshal, Karni S.; Camel, Clacy K.; Kartha, Ganesh K.; Steed, Mesia M.; Tyagi, Neetu; Sen, Utpal; Kang, Yujian; Lominadze, David; Maldonado, Claudio; Tyagi, Suresh C.

In: Current Neurovascular Research, Vol. 4, No. 4, 01.11.2007, p. 289-294.

Research output: Contribution to journalReview article

Moshal, KS, Camel, CK, Kartha, GK, Steed, MM, Tyagi, N, Sen, U, Kang, Y, Lominadze, D, Maldonado, C & Tyagi, SC 2007, 'Cardiac Dys-synchronization and arrhythmia in hyperhomocysteinemia', Current Neurovascular Research, vol. 4, no. 4, pp. 289-294. https://doi.org/10.2174/156720207782446324
Moshal KS, Camel CK, Kartha GK, Steed MM, Tyagi N, Sen U et al. Cardiac Dys-synchronization and arrhythmia in hyperhomocysteinemia. Current Neurovascular Research. 2007 Nov 1;4(4):289-294. https://doi.org/10.2174/156720207782446324
Moshal, Karni S. ; Camel, Clacy K. ; Kartha, Ganesh K. ; Steed, Mesia M. ; Tyagi, Neetu ; Sen, Utpal ; Kang, Yujian ; Lominadze, David ; Maldonado, Claudio ; Tyagi, Suresh C. / Cardiac Dys-synchronization and arrhythmia in hyperhomocysteinemia. In: Current Neurovascular Research. 2007 ; Vol. 4, No. 4. pp. 289-294.
@article{5550041d62264856b04986451fafd632,
title = "Cardiac Dys-synchronization and arrhythmia in hyperhomocysteinemia",
abstract = "Although cardiac synchronization is important in maintaining myocardial performance, the mechanism of dys-synchronization in ailing to failing myocardium is unclear. It is known that the cardiac myocyte contracts and relaxes individually; however, it synchronizes only when connected to one another by low resistance communications called gap junction protein (connexins) and extra cellular matrix (ECM). Therefore, the remodeling of connexins and ECM in heart failure plays an important role in cardiac conduction, synchronization and arrhythmias. This review for the first time addresses the role of systemic accumulation of homocysteine (Hcy) in vasospasm, pressure and volume overload heart failure, hypertension and cardiac arrhythmias. The attenuation of calcium-dependent mitochondrial (mt), endothelial and neuronal nitric oxide synthase (mtNOS, eNOS and nNOS) by Hcy plays a significant role in cardiac arrhythmias. The signal transduction mechanisms in Hcy-induced matrix metalloproteinase (MMP) activation in cardiac connexin remodeling are discussed.",
author = "Moshal, {Karni S.} and Camel, {Clacy K.} and Kartha, {Ganesh K.} and Steed, {Mesia M.} and Neetu Tyagi and Utpal Sen and Yujian Kang and David Lominadze and Claudio Maldonado and Tyagi, {Suresh C.}",
year = "2007",
month = "11",
day = "1",
doi = "10.2174/156720207782446324",
language = "English (US)",
volume = "4",
pages = "289--294",
journal = "Current Neurovascular Research",
issn = "1567-2026",
publisher = "Bentham Science Publishers B.V.",
number = "4",

}

TY - JOUR

T1 - Cardiac Dys-synchronization and arrhythmia in hyperhomocysteinemia

AU - Moshal, Karni S.

AU - Camel, Clacy K.

AU - Kartha, Ganesh K.

AU - Steed, Mesia M.

AU - Tyagi, Neetu

AU - Sen, Utpal

AU - Kang, Yujian

AU - Lominadze, David

AU - Maldonado, Claudio

AU - Tyagi, Suresh C.

PY - 2007/11/1

Y1 - 2007/11/1

N2 - Although cardiac synchronization is important in maintaining myocardial performance, the mechanism of dys-synchronization in ailing to failing myocardium is unclear. It is known that the cardiac myocyte contracts and relaxes individually; however, it synchronizes only when connected to one another by low resistance communications called gap junction protein (connexins) and extra cellular matrix (ECM). Therefore, the remodeling of connexins and ECM in heart failure plays an important role in cardiac conduction, synchronization and arrhythmias. This review for the first time addresses the role of systemic accumulation of homocysteine (Hcy) in vasospasm, pressure and volume overload heart failure, hypertension and cardiac arrhythmias. The attenuation of calcium-dependent mitochondrial (mt), endothelial and neuronal nitric oxide synthase (mtNOS, eNOS and nNOS) by Hcy plays a significant role in cardiac arrhythmias. The signal transduction mechanisms in Hcy-induced matrix metalloproteinase (MMP) activation in cardiac connexin remodeling are discussed.

AB - Although cardiac synchronization is important in maintaining myocardial performance, the mechanism of dys-synchronization in ailing to failing myocardium is unclear. It is known that the cardiac myocyte contracts and relaxes individually; however, it synchronizes only when connected to one another by low resistance communications called gap junction protein (connexins) and extra cellular matrix (ECM). Therefore, the remodeling of connexins and ECM in heart failure plays an important role in cardiac conduction, synchronization and arrhythmias. This review for the first time addresses the role of systemic accumulation of homocysteine (Hcy) in vasospasm, pressure and volume overload heart failure, hypertension and cardiac arrhythmias. The attenuation of calcium-dependent mitochondrial (mt), endothelial and neuronal nitric oxide synthase (mtNOS, eNOS and nNOS) by Hcy plays a significant role in cardiac arrhythmias. The signal transduction mechanisms in Hcy-induced matrix metalloproteinase (MMP) activation in cardiac connexin remodeling are discussed.

UR - http://www.scopus.com/inward/record.url?scp=36448997797&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36448997797&partnerID=8YFLogxK

U2 - 10.2174/156720207782446324

DO - 10.2174/156720207782446324

M3 - Review article

VL - 4

SP - 289

EP - 294

JO - Current Neurovascular Research

JF - Current Neurovascular Research

SN - 1567-2026

IS - 4

ER -