Cardiac evaluation before kidney transplantation

A practice patterns analysis in medicare-insured dialysis patients

Krista L. Lentine, Mark A. Schnitzler, Daniel C. Brennan, Jon J. Snyder, Paul Hauptman, Kevin C. Abbott, David Axelrod, Paolo R. Salvalaggio, Bertram Kasiske

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background and objectives: Evaluation for ischemic heart disease (IHD) is a nonstandardized practice before kidney transplantation. We retrospectively studied pretransplant cardiac evaluation (CE) practices in a national sample of renal allograft recipients. Design, setting, participants, & measurements: The USRDS data for Medicare beneficiaries transplanted in 1991 to 2004 with Part A&B benefits from dialysis initiation through transplantation were examined. Clinical traits defining "high" expected IHD risk were defined as diabetes, prior IHD, or ≥ 2 other coronary risk factors. Pretransplant CE were identified by billing claims for noninvasive stress tests and angiography. Patients were quantified with claims for coronary revascularization procedures between CE and transplant. Post-transplant acute myocardial infarction (AMI) events were abstracted from claims and death records. Results: Among 27,786 eligible patients, 46.3% underwent CE before transplantation. Overall, 9.5% who received CE also received pretransplant revascularization, but only 0.3% of lower-risk patients undergoing CE had revascularization. The adjusted odds of transplant without CE increased sharply with younger age and shorter dialysis duration. Increased likelihood of transplant without CE also correlated with black race, female sex, and certain geographic regions. Among patients transplanted without CE, 3-yr incidence of post-transplant AMI was 3% in lower-risk and 10% in high-risk groups, and varied by individual traits within these groups. Among lower-risk patients transplanted without CE, blacks were higher risk for AMI than whites (adjusted hazards ratio 1.47, 95% CI 1.11-1.93). Conclusions: Observed practices demonstrate infrequent use of pretransplant revascularization after CE but also raise concern for socio-demographic barriers to evaluation access.

Original languageEnglish (US)
Pages (from-to)1115-1124
Number of pages10
JournalClinical Journal of the American Society of Nephrology
Volume3
Issue number4
DOIs
StatePublished - Jul 1 2008

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Medicare
Kidney Transplantation
Dialysis
Transplants
Myocardial Ischemia
Myocardial Infarction
Transplantation
Death Certificates
Exercise Test
Allografts
Angiography
Demography

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

Cite this

Cardiac evaluation before kidney transplantation : A practice patterns analysis in medicare-insured dialysis patients. / Lentine, Krista L.; Schnitzler, Mark A.; Brennan, Daniel C.; Snyder, Jon J.; Hauptman, Paul; Abbott, Kevin C.; Axelrod, David; Salvalaggio, Paolo R.; Kasiske, Bertram.

In: Clinical Journal of the American Society of Nephrology, Vol. 3, No. 4, 01.07.2008, p. 1115-1124.

Research output: Contribution to journalArticle

Lentine, KL, Schnitzler, MA, Brennan, DC, Snyder, JJ, Hauptman, P, Abbott, KC, Axelrod, D, Salvalaggio, PR & Kasiske, B 2008, 'Cardiac evaluation before kidney transplantation: A practice patterns analysis in medicare-insured dialysis patients', Clinical Journal of the American Society of Nephrology, vol. 3, no. 4, pp. 1115-1124. https://doi.org/10.2215/CJN.05351107
Lentine, Krista L. ; Schnitzler, Mark A. ; Brennan, Daniel C. ; Snyder, Jon J. ; Hauptman, Paul ; Abbott, Kevin C. ; Axelrod, David ; Salvalaggio, Paolo R. ; Kasiske, Bertram. / Cardiac evaluation before kidney transplantation : A practice patterns analysis in medicare-insured dialysis patients. In: Clinical Journal of the American Society of Nephrology. 2008 ; Vol. 3, No. 4. pp. 1115-1124.
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abstract = "Background and objectives: Evaluation for ischemic heart disease (IHD) is a nonstandardized practice before kidney transplantation. We retrospectively studied pretransplant cardiac evaluation (CE) practices in a national sample of renal allograft recipients. Design, setting, participants, & measurements: The USRDS data for Medicare beneficiaries transplanted in 1991 to 2004 with Part A&B benefits from dialysis initiation through transplantation were examined. Clinical traits defining {"}high{"} expected IHD risk were defined as diabetes, prior IHD, or ≥ 2 other coronary risk factors. Pretransplant CE were identified by billing claims for noninvasive stress tests and angiography. Patients were quantified with claims for coronary revascularization procedures between CE and transplant. Post-transplant acute myocardial infarction (AMI) events were abstracted from claims and death records. Results: Among 27,786 eligible patients, 46.3{\%} underwent CE before transplantation. Overall, 9.5{\%} who received CE also received pretransplant revascularization, but only 0.3{\%} of lower-risk patients undergoing CE had revascularization. The adjusted odds of transplant without CE increased sharply with younger age and shorter dialysis duration. Increased likelihood of transplant without CE also correlated with black race, female sex, and certain geographic regions. Among patients transplanted without CE, 3-yr incidence of post-transplant AMI was 3{\%} in lower-risk and 10{\%} in high-risk groups, and varied by individual traits within these groups. Among lower-risk patients transplanted without CE, blacks were higher risk for AMI than whites (adjusted hazards ratio 1.47, 95{\%} CI 1.11-1.93). Conclusions: Observed practices demonstrate infrequent use of pretransplant revascularization after CE but also raise concern for socio-demographic barriers to evaluation access.",
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AU - Brennan, Daniel C.

AU - Snyder, Jon J.

AU - Hauptman, Paul

AU - Abbott, Kevin C.

AU - Axelrod, David

AU - Salvalaggio, Paolo R.

AU - Kasiske, Bertram

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N2 - Background and objectives: Evaluation for ischemic heart disease (IHD) is a nonstandardized practice before kidney transplantation. We retrospectively studied pretransplant cardiac evaluation (CE) practices in a national sample of renal allograft recipients. Design, setting, participants, & measurements: The USRDS data for Medicare beneficiaries transplanted in 1991 to 2004 with Part A&B benefits from dialysis initiation through transplantation were examined. Clinical traits defining "high" expected IHD risk were defined as diabetes, prior IHD, or ≥ 2 other coronary risk factors. Pretransplant CE were identified by billing claims for noninvasive stress tests and angiography. Patients were quantified with claims for coronary revascularization procedures between CE and transplant. Post-transplant acute myocardial infarction (AMI) events were abstracted from claims and death records. Results: Among 27,786 eligible patients, 46.3% underwent CE before transplantation. Overall, 9.5% who received CE also received pretransplant revascularization, but only 0.3% of lower-risk patients undergoing CE had revascularization. The adjusted odds of transplant without CE increased sharply with younger age and shorter dialysis duration. Increased likelihood of transplant without CE also correlated with black race, female sex, and certain geographic regions. Among patients transplanted without CE, 3-yr incidence of post-transplant AMI was 3% in lower-risk and 10% in high-risk groups, and varied by individual traits within these groups. Among lower-risk patients transplanted without CE, blacks were higher risk for AMI than whites (adjusted hazards ratio 1.47, 95% CI 1.11-1.93). Conclusions: Observed practices demonstrate infrequent use of pretransplant revascularization after CE but also raise concern for socio-demographic barriers to evaluation access.

AB - Background and objectives: Evaluation for ischemic heart disease (IHD) is a nonstandardized practice before kidney transplantation. We retrospectively studied pretransplant cardiac evaluation (CE) practices in a national sample of renal allograft recipients. Design, setting, participants, & measurements: The USRDS data for Medicare beneficiaries transplanted in 1991 to 2004 with Part A&B benefits from dialysis initiation through transplantation were examined. Clinical traits defining "high" expected IHD risk were defined as diabetes, prior IHD, or ≥ 2 other coronary risk factors. Pretransplant CE were identified by billing claims for noninvasive stress tests and angiography. Patients were quantified with claims for coronary revascularization procedures between CE and transplant. Post-transplant acute myocardial infarction (AMI) events were abstracted from claims and death records. Results: Among 27,786 eligible patients, 46.3% underwent CE before transplantation. Overall, 9.5% who received CE also received pretransplant revascularization, but only 0.3% of lower-risk patients undergoing CE had revascularization. The adjusted odds of transplant without CE increased sharply with younger age and shorter dialysis duration. Increased likelihood of transplant without CE also correlated with black race, female sex, and certain geographic regions. Among patients transplanted without CE, 3-yr incidence of post-transplant AMI was 3% in lower-risk and 10% in high-risk groups, and varied by individual traits within these groups. Among lower-risk patients transplanted without CE, blacks were higher risk for AMI than whites (adjusted hazards ratio 1.47, 95% CI 1.11-1.93). Conclusions: Observed practices demonstrate infrequent use of pretransplant revascularization after CE but also raise concern for socio-demographic barriers to evaluation access.

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