Cardiac transplantation without cardiopulmonary bypass

Experimental model to study growth of the transplanted heart

Peter Mckeown, K. Tabayashi, M. Miyamoto, R. Thomas, T. Togo, H. Tsuboi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

An experimental model using surface-induced (20° C) deep hypothermia and total circulatory arrest instead of cardiopulmonary bypass was developed for the study of growth of the transplanted heart. Autotransplantation of the heart was performed in 42 young dogs weighing from 4.4 to 9.0 kg (mean, 6.9 kg). Time of ischemia ranged from 26.0 to 60 minutes (mean, 43.4 minutes). Return of satisfactory cardiac function occurred in all but one animal. An early high mortality rate was due primarily to pulmonary complications, but with modifications to the technique, long-term survival increased to 70%. Early deaths (5 days to 13 weeks) of five dogs during preliminary trials were due to pleural effusion (2), sepsis (1), endocarditis (1), and ascites (1). There have been 14 long-term survivors (range, 194 to 498 days; mean, 264 days). Long-term survivors appear well, are active, and show satisfactory growth. This experimental model eliminates the need for heparinization and reduces the potential for complications associated with cardiopulmonary bypass in the dog. It avoids cannulations that might impinge on anastomotic sites. This model appears to be suited for studying growth of the transplanted heart.

Original languageEnglish (US)
Pages (from-to)489-493
Number of pages5
JournalSurgery
Volume104
Issue number3
StatePublished - Jan 1 1988
Externally publishedYes

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Heart Transplantation
Cardiopulmonary Bypass
Theoretical Models
Dogs
Survivors
Growth
Autologous Transplantation
Pleural Effusion
Endocarditis
Hypothermia
Ascites
Catheterization
Sepsis
Ischemia
Lung
Survival
Mortality

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Mckeown, P., Tabayashi, K., Miyamoto, M., Thomas, R., Togo, T., & Tsuboi, H. (1988). Cardiac transplantation without cardiopulmonary bypass: Experimental model to study growth of the transplanted heart. Surgery, 104(3), 489-493.

Cardiac transplantation without cardiopulmonary bypass : Experimental model to study growth of the transplanted heart. / Mckeown, Peter; Tabayashi, K.; Miyamoto, M.; Thomas, R.; Togo, T.; Tsuboi, H.

In: Surgery, Vol. 104, No. 3, 01.01.1988, p. 489-493.

Research output: Contribution to journalArticle

Mckeown, P, Tabayashi, K, Miyamoto, M, Thomas, R, Togo, T & Tsuboi, H 1988, 'Cardiac transplantation without cardiopulmonary bypass: Experimental model to study growth of the transplanted heart', Surgery, vol. 104, no. 3, pp. 489-493.
Mckeown, Peter ; Tabayashi, K. ; Miyamoto, M. ; Thomas, R. ; Togo, T. ; Tsuboi, H. / Cardiac transplantation without cardiopulmonary bypass : Experimental model to study growth of the transplanted heart. In: Surgery. 1988 ; Vol. 104, No. 3. pp. 489-493.
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