Cardiopulmonary function after pulmonary contusion and partial liquid ventilation

Charles B. Moomey, Timothy C. Fabian, Martin Croce, Sherry M. Melton, Kenneth G. Proctor

Research output: Contribution to journalArticle

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Abstract

Purpose: To compare the effects of mechanical ventilation with either positive end-expiratory pressure (PEEP) or partial liquid ventilation (PLV) on cardiopulmonary function after severe pulmonary contusion. Methods: Mongrel pigs (32 ± 1 kg) were anesthetized, paralyzed, and mechanically ventilated (8-10 mL/kg tidal volume; 12 breaths/min; FiO2 = 0.5). Systemic hemodynamics and pulmonary function were measured for 7 hours after a captive bolt gun delivered a blunt injury to the right chest. After 5 hours, FiO2 was increased to 1.0 and either PEEP (n = 7) in titrated increments to 25 cm H2O or PLV with perflubron (LiquiVent, 30 mL/kg, endotracheal) and no PEEP (n = 7) was administered for 2 hours. Two control groups received injury without treatment (n = 6) or no injury with PLV (n = 3). Fluids were liberalized with PEEP versus PLV (27 ± 3 vs. 18 ± 2 mL · kg-1 · h-1) to maintain cardiac filling pressures. Results: Before treatment at 5 hours after injury, physiologic dead space fraction (30 ± 4%), pulmonary vascular resistance (224 ± 20% of baseline), and airway resistance (437 ± 110% of baseline) were all increased (p < 0.05). In addition, PaO2/FiO2 had decreased to 112 ± 18 mm Hg, compliance was depressed to 11 ± 1 mL/cm H2O (36 ± 3% of baseline), and shunt fraction was increased to 22 ± 4% (all p < 0.05). Blood pressure and cardiac index remained stable relative to baseline, but stroke index and systemic oxygen delivery were depressed by 15 to 30% (both p < 0.05). After 2 hours of treatment with PEEP versus PLV, PO2/FiO2 was higher (427 ± 20 vs. 263 ± 37) and dead space ventilation was lower (4 ± 3 vs. 28 ± 7%) (both p < 0.05), whereas compliance tended to be higher (26 ± 2 vs. 20 ± 2) and shunt fraction tended to be lower (0 ± 0 vs. 7 ± 4). With PEEP versus PLV, however, cardiac index, stroke index, and systemic oxygen delivery were 30 to 60% lower (all p < 0.05). Furthermore, although contused lungs showed similar damage with either treatment, the secondary injury in the contralateral lung (as manifested by intra-alveolar hemorrhage) was more severe with PEEP than with PLV. Conclusions: Both PEEP and PLV improved pulmonary function after severe unilateral pulmonary contusion, but negative hemodynamic and histologic changes were associated with PEEP and not with PLV. These data suggest that PLV is a promising novel ventilatory strategy for unilateral pulmonary contusion that might ameliorate secondary injury in the contralateral uninjured lung.

Original languageEnglish (US)
Pages (from-to)283-290
Number of pages8
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume45
Issue number2
DOIs
StatePublished - Jan 1 1998

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Liquid Ventilation
Contusions
Positive-Pressure Respiration
Lung
Wounds and Injuries
Compliance
Hemodynamics
Stroke
Oxygen
Nonpenetrating Wounds
Airway Resistance
Tidal Volume
Firearms
Therapeutics
Artificial Respiration
Vascular Resistance
Ventilation
Swine
Thorax

All Science Journal Classification (ASJC) codes

  • Surgery
  • Critical Care and Intensive Care Medicine

Cite this

Cardiopulmonary function after pulmonary contusion and partial liquid ventilation. / Moomey, Charles B.; Fabian, Timothy C.; Croce, Martin; Melton, Sherry M.; Proctor, Kenneth G.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 45, No. 2, 01.01.1998, p. 283-290.

Research output: Contribution to journalArticle

Moomey, Charles B. ; Fabian, Timothy C. ; Croce, Martin ; Melton, Sherry M. ; Proctor, Kenneth G. / Cardiopulmonary function after pulmonary contusion and partial liquid ventilation. In: Journal of Trauma - Injury, Infection and Critical Care. 1998 ; Vol. 45, No. 2. pp. 283-290.
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abstract = "Purpose: To compare the effects of mechanical ventilation with either positive end-expiratory pressure (PEEP) or partial liquid ventilation (PLV) on cardiopulmonary function after severe pulmonary contusion. Methods: Mongrel pigs (32 ± 1 kg) were anesthetized, paralyzed, and mechanically ventilated (8-10 mL/kg tidal volume; 12 breaths/min; FiO2 = 0.5). Systemic hemodynamics and pulmonary function were measured for 7 hours after a captive bolt gun delivered a blunt injury to the right chest. After 5 hours, FiO2 was increased to 1.0 and either PEEP (n = 7) in titrated increments to 25 cm H2O or PLV with perflubron (LiquiVent, 30 mL/kg, endotracheal) and no PEEP (n = 7) was administered for 2 hours. Two control groups received injury without treatment (n = 6) or no injury with PLV (n = 3). Fluids were liberalized with PEEP versus PLV (27 ± 3 vs. 18 ± 2 mL · kg-1 · h-1) to maintain cardiac filling pressures. Results: Before treatment at 5 hours after injury, physiologic dead space fraction (30 ± 4{\%}), pulmonary vascular resistance (224 ± 20{\%} of baseline), and airway resistance (437 ± 110{\%} of baseline) were all increased (p < 0.05). In addition, PaO2/FiO2 had decreased to 112 ± 18 mm Hg, compliance was depressed to 11 ± 1 mL/cm H2O (36 ± 3{\%} of baseline), and shunt fraction was increased to 22 ± 4{\%} (all p < 0.05). Blood pressure and cardiac index remained stable relative to baseline, but stroke index and systemic oxygen delivery were depressed by 15 to 30{\%} (both p < 0.05). After 2 hours of treatment with PEEP versus PLV, PO2/FiO2 was higher (427 ± 20 vs. 263 ± 37) and dead space ventilation was lower (4 ± 3 vs. 28 ± 7{\%}) (both p < 0.05), whereas compliance tended to be higher (26 ± 2 vs. 20 ± 2) and shunt fraction tended to be lower (0 ± 0 vs. 7 ± 4). With PEEP versus PLV, however, cardiac index, stroke index, and systemic oxygen delivery were 30 to 60{\%} lower (all p < 0.05). Furthermore, although contused lungs showed similar damage with either treatment, the secondary injury in the contralateral lung (as manifested by intra-alveolar hemorrhage) was more severe with PEEP than with PLV. Conclusions: Both PEEP and PLV improved pulmonary function after severe unilateral pulmonary contusion, but negative hemodynamic and histologic changes were associated with PEEP and not with PLV. These data suggest that PLV is a promising novel ventilatory strategy for unilateral pulmonary contusion that might ameliorate secondary injury in the contralateral uninjured lung.",
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AU - Croce, Martin

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AU - Proctor, Kenneth G.

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N2 - Purpose: To compare the effects of mechanical ventilation with either positive end-expiratory pressure (PEEP) or partial liquid ventilation (PLV) on cardiopulmonary function after severe pulmonary contusion. Methods: Mongrel pigs (32 ± 1 kg) were anesthetized, paralyzed, and mechanically ventilated (8-10 mL/kg tidal volume; 12 breaths/min; FiO2 = 0.5). Systemic hemodynamics and pulmonary function were measured for 7 hours after a captive bolt gun delivered a blunt injury to the right chest. After 5 hours, FiO2 was increased to 1.0 and either PEEP (n = 7) in titrated increments to 25 cm H2O or PLV with perflubron (LiquiVent, 30 mL/kg, endotracheal) and no PEEP (n = 7) was administered for 2 hours. Two control groups received injury without treatment (n = 6) or no injury with PLV (n = 3). Fluids were liberalized with PEEP versus PLV (27 ± 3 vs. 18 ± 2 mL · kg-1 · h-1) to maintain cardiac filling pressures. Results: Before treatment at 5 hours after injury, physiologic dead space fraction (30 ± 4%), pulmonary vascular resistance (224 ± 20% of baseline), and airway resistance (437 ± 110% of baseline) were all increased (p < 0.05). In addition, PaO2/FiO2 had decreased to 112 ± 18 mm Hg, compliance was depressed to 11 ± 1 mL/cm H2O (36 ± 3% of baseline), and shunt fraction was increased to 22 ± 4% (all p < 0.05). Blood pressure and cardiac index remained stable relative to baseline, but stroke index and systemic oxygen delivery were depressed by 15 to 30% (both p < 0.05). After 2 hours of treatment with PEEP versus PLV, PO2/FiO2 was higher (427 ± 20 vs. 263 ± 37) and dead space ventilation was lower (4 ± 3 vs. 28 ± 7%) (both p < 0.05), whereas compliance tended to be higher (26 ± 2 vs. 20 ± 2) and shunt fraction tended to be lower (0 ± 0 vs. 7 ± 4). With PEEP versus PLV, however, cardiac index, stroke index, and systemic oxygen delivery were 30 to 60% lower (all p < 0.05). Furthermore, although contused lungs showed similar damage with either treatment, the secondary injury in the contralateral lung (as manifested by intra-alveolar hemorrhage) was more severe with PEEP than with PLV. Conclusions: Both PEEP and PLV improved pulmonary function after severe unilateral pulmonary contusion, but negative hemodynamic and histologic changes were associated with PEEP and not with PLV. These data suggest that PLV is a promising novel ventilatory strategy for unilateral pulmonary contusion that might ameliorate secondary injury in the contralateral uninjured lung.

AB - Purpose: To compare the effects of mechanical ventilation with either positive end-expiratory pressure (PEEP) or partial liquid ventilation (PLV) on cardiopulmonary function after severe pulmonary contusion. Methods: Mongrel pigs (32 ± 1 kg) were anesthetized, paralyzed, and mechanically ventilated (8-10 mL/kg tidal volume; 12 breaths/min; FiO2 = 0.5). Systemic hemodynamics and pulmonary function were measured for 7 hours after a captive bolt gun delivered a blunt injury to the right chest. After 5 hours, FiO2 was increased to 1.0 and either PEEP (n = 7) in titrated increments to 25 cm H2O or PLV with perflubron (LiquiVent, 30 mL/kg, endotracheal) and no PEEP (n = 7) was administered for 2 hours. Two control groups received injury without treatment (n = 6) or no injury with PLV (n = 3). Fluids were liberalized with PEEP versus PLV (27 ± 3 vs. 18 ± 2 mL · kg-1 · h-1) to maintain cardiac filling pressures. Results: Before treatment at 5 hours after injury, physiologic dead space fraction (30 ± 4%), pulmonary vascular resistance (224 ± 20% of baseline), and airway resistance (437 ± 110% of baseline) were all increased (p < 0.05). In addition, PaO2/FiO2 had decreased to 112 ± 18 mm Hg, compliance was depressed to 11 ± 1 mL/cm H2O (36 ± 3% of baseline), and shunt fraction was increased to 22 ± 4% (all p < 0.05). Blood pressure and cardiac index remained stable relative to baseline, but stroke index and systemic oxygen delivery were depressed by 15 to 30% (both p < 0.05). After 2 hours of treatment with PEEP versus PLV, PO2/FiO2 was higher (427 ± 20 vs. 263 ± 37) and dead space ventilation was lower (4 ± 3 vs. 28 ± 7%) (both p < 0.05), whereas compliance tended to be higher (26 ± 2 vs. 20 ± 2) and shunt fraction tended to be lower (0 ± 0 vs. 7 ± 4). With PEEP versus PLV, however, cardiac index, stroke index, and systemic oxygen delivery were 30 to 60% lower (all p < 0.05). Furthermore, although contused lungs showed similar damage with either treatment, the secondary injury in the contralateral lung (as manifested by intra-alveolar hemorrhage) was more severe with PEEP than with PLV. Conclusions: Both PEEP and PLV improved pulmonary function after severe unilateral pulmonary contusion, but negative hemodynamic and histologic changes were associated with PEEP and not with PLV. These data suggest that PLV is a promising novel ventilatory strategy for unilateral pulmonary contusion that might ameliorate secondary injury in the contralateral uninjured lung.

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