Cardiorenal Syndrome Type 3

Teena P. Zachariah, Vasanthi Balaraman, R. John Crew

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cardiorenal syndrome type 3 refers to the impact of acute kidney injury (AKI) on cardiac function. AKI is very common among hospitalized patients worldwide, with reported rates largely dependent on the setting and the cause of hospitalization. In its most severe form, AKI can cause obvious changes in cardiac function - hyperkalemia leading to arrhythmias, fluid overload leading to congestive heart failure/pulmonary edema, and acidosis leading to impaired contractility. However, it is clear that subtle changes in the setting of mild episodes of renal injury have long-term effects. Separate from altered fluid balance and electrolyte abnormalities, AKI events frequently are associated with alterations in inflammatory markers that may contribute to cardiac inflammation, hypertrophy, and atherosclerosis. Given the frequency of AKI events and the potential long-term impact, we need to improve our understanding and identify potential therapeutic targets to lessen the long-term injury related to AKI events.

Original languageEnglish (US)
Title of host publicationCritical Care Nephrology
Subtitle of host publicationThird Edition
PublisherElsevier Inc.
Pages695-701.e2
ISBN (Electronic)9780323449427
ISBN (Print)9780323449427
DOIs
StatePublished - Jan 1 2019

Fingerprint

Cardio-Renal Syndrome
Acute Kidney Injury
Hyperkalemia
Water-Electrolyte Balance
Wounds and Injuries
Cardiomegaly
Pulmonary Edema
Acidosis
Electrolytes
Cardiac Arrhythmias
Atherosclerosis
Hospitalization
Heart Failure
Inflammation
Kidney

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Zachariah, T. P., Balaraman, V., & Crew, R. J. (2019). Cardiorenal Syndrome Type 3. In Critical Care Nephrology: Third Edition (pp. 695-701.e2). Elsevier Inc.. https://doi.org/10.1016/B978-0-323-44942-7.00113-8

Cardiorenal Syndrome Type 3. / Zachariah, Teena P.; Balaraman, Vasanthi; Crew, R. John.

Critical Care Nephrology: Third Edition. Elsevier Inc., 2019. p. 695-701.e2.

Research output: Chapter in Book/Report/Conference proceedingChapter

Zachariah, TP, Balaraman, V & Crew, RJ 2019, Cardiorenal Syndrome Type 3. in Critical Care Nephrology: Third Edition. Elsevier Inc., pp. 695-701.e2. https://doi.org/10.1016/B978-0-323-44942-7.00113-8
Zachariah TP, Balaraman V, Crew RJ. Cardiorenal Syndrome Type 3. In Critical Care Nephrology: Third Edition. Elsevier Inc. 2019. p. 695-701.e2 https://doi.org/10.1016/B978-0-323-44942-7.00113-8
Zachariah, Teena P. ; Balaraman, Vasanthi ; Crew, R. John. / Cardiorenal Syndrome Type 3. Critical Care Nephrology: Third Edition. Elsevier Inc., 2019. pp. 695-701.e2
@inbook{ed6f60f706e94d71a933823c451a169f,
title = "Cardiorenal Syndrome Type 3",
abstract = "Cardiorenal syndrome type 3 refers to the impact of acute kidney injury (AKI) on cardiac function. AKI is very common among hospitalized patients worldwide, with reported rates largely dependent on the setting and the cause of hospitalization. In its most severe form, AKI can cause obvious changes in cardiac function - hyperkalemia leading to arrhythmias, fluid overload leading to congestive heart failure/pulmonary edema, and acidosis leading to impaired contractility. However, it is clear that subtle changes in the setting of mild episodes of renal injury have long-term effects. Separate from altered fluid balance and electrolyte abnormalities, AKI events frequently are associated with alterations in inflammatory markers that may contribute to cardiac inflammation, hypertrophy, and atherosclerosis. Given the frequency of AKI events and the potential long-term impact, we need to improve our understanding and identify potential therapeutic targets to lessen the long-term injury related to AKI events.",
author = "Zachariah, {Teena P.} and Vasanthi Balaraman and Crew, {R. John}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/B978-0-323-44942-7.00113-8",
language = "English (US)",
isbn = "9780323449427",
pages = "695--701.e2",
booktitle = "Critical Care Nephrology",
publisher = "Elsevier Inc.",
address = "United States",

}

TY - CHAP

T1 - Cardiorenal Syndrome Type 3

AU - Zachariah, Teena P.

AU - Balaraman, Vasanthi

AU - Crew, R. John

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Cardiorenal syndrome type 3 refers to the impact of acute kidney injury (AKI) on cardiac function. AKI is very common among hospitalized patients worldwide, with reported rates largely dependent on the setting and the cause of hospitalization. In its most severe form, AKI can cause obvious changes in cardiac function - hyperkalemia leading to arrhythmias, fluid overload leading to congestive heart failure/pulmonary edema, and acidosis leading to impaired contractility. However, it is clear that subtle changes in the setting of mild episodes of renal injury have long-term effects. Separate from altered fluid balance and electrolyte abnormalities, AKI events frequently are associated with alterations in inflammatory markers that may contribute to cardiac inflammation, hypertrophy, and atherosclerosis. Given the frequency of AKI events and the potential long-term impact, we need to improve our understanding and identify potential therapeutic targets to lessen the long-term injury related to AKI events.

AB - Cardiorenal syndrome type 3 refers to the impact of acute kidney injury (AKI) on cardiac function. AKI is very common among hospitalized patients worldwide, with reported rates largely dependent on the setting and the cause of hospitalization. In its most severe form, AKI can cause obvious changes in cardiac function - hyperkalemia leading to arrhythmias, fluid overload leading to congestive heart failure/pulmonary edema, and acidosis leading to impaired contractility. However, it is clear that subtle changes in the setting of mild episodes of renal injury have long-term effects. Separate from altered fluid balance and electrolyte abnormalities, AKI events frequently are associated with alterations in inflammatory markers that may contribute to cardiac inflammation, hypertrophy, and atherosclerosis. Given the frequency of AKI events and the potential long-term impact, we need to improve our understanding and identify potential therapeutic targets to lessen the long-term injury related to AKI events.

UR - http://www.scopus.com/inward/record.url?scp=85055384618&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055384618&partnerID=8YFLogxK

U2 - 10.1016/B978-0-323-44942-7.00113-8

DO - 10.1016/B978-0-323-44942-7.00113-8

M3 - Chapter

SN - 9780323449427

SP - 695-701.e2

BT - Critical Care Nephrology

PB - Elsevier Inc.

ER -