Cardiovascular responses to cold exposure

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

The prevalence of hypertension is increased in winter and in cold regions of the world. Cold temperatures make hypertension worse and trigger cardiovascular complications (stroke, myocardial infarction, heart failure, etc.). Chronic or intermittent exposure to cold causes hypertension and cardiac hypertrophy in animals. The purpose of this review is to provide the recent advances in the mechanistic investigation of cold-induced hypertension (CIH). Cold temperatures increase the activities of the sympathetic nervous system (SNS) and the reninangiotensin system (RAS). The SNS initiates CIH via the RAS. Cold exposure suppresses the expression of eNOS and formation of NO, increases the production of endothelin-1 (ET-1), up-regulates ETA receptors, but downregulates ETB receptors. The roles of these factors and their relations in CIH will be reviewed.

Original languageEnglish (US)
Pages (from-to)495-503
Number of pages9
JournalFrontiers in Bioscience - Elite
Volume2 E
Issue number2
StatePublished - Jan 1 2010
Externally publishedYes

Fingerprint

Neurology
Endothelin-1
Hypertension
Animals
Temperature
Sympathetic Nervous System
Myocardial Infarction
Cardiomegaly
Up-Regulation
Down-Regulation
Heart Failure

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Cardiovascular responses to cold exposure. / Sun, Zhongjie.

In: Frontiers in Bioscience - Elite, Vol. 2 E, No. 2, 01.01.2010, p. 495-503.

Research output: Contribution to journalArticle

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