Carnitine palmitoyltransferase expression in rat heart is altered by diabetes

Research output: Contribution to journalArticle

Abstract

Cardiac venicular myocytes are the only cells that have been shown lo possess two isofnrnis of carnitine palrnitoyltransferase 1 (CPTI), the highly regulated rate controlling enzyme of fatty acid oxidation. CPT1a is found in most cells including the liver, kidney, brain. etc.: CPTM is found in skeletal m u M le ,:ii<l ,i(li|)ose cells. We have shown previously i hat CPT1a is increased in lie liver during, iiiMilin-depenilenl diabetes (both en/ynie activity and niRNA abundance), and we have .shown that insu lin decreases the expression of CPT la in H 11IK hepa'nma cells. However, neither CP'I'la nur CPT1J have been shown to be hunmmally regulated in the henrt. Tsing Northern analysis of total heart UNA we examined CPTln and (TTU mRNA abundance in normal and strepto/otocin diabetic rats and found both isoforms to be substantially increased in the liiabetic state. Hoth isotorms were also found of be elevated in rat heart after a H-hour fast, just as CPTI is increased in rat liver. 1 hese data indicate thai CPTlo and CPT1β mRNA expression is regulated in the heart during fasting and diabetes, but the exact mechanism controlling fatty arid oxidation is yet to be established. (THIS WORK WAS SUPPORTED HY A GRANT FROM THE AMERICAN HEART ASSOCIATION.

Original languageEnglish (US)
JournalFASEB Journal
Volume12
Issue number8
StatePublished - 1998

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Carnitine O-Palmitoyltransferase
carnitine palmitoyltransferase
Medical problems
diabetes
Rats
heart
Liver
rats
American Heart Association
Oxidation
Messenger RNA
liver
beta oxidation
Carnitine
carnitine
Organized Financing
cells
Cardiac Myocytes
hepatocytes
fasting

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Carnitine palmitoyltransferase expression in rat heart is altered by diabetes. / Cook, George; Park, Edwards.

In: FASEB Journal, Vol. 12, No. 8, 1998.

Research output: Contribution to journalArticle

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