Carotid arterial stiffness as a surrogate for aortic stiffness

Relationship between carotid artery pressure-strain elastic modulus and aortic pulse wave velocity

Yoji Nagai, Jerome L. Fleg, Mary K. Kemper, Tomasz M. Rywik, Christopher J. Earley, E. Metter

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Common carotid arterial (CCA) stiffness can be assessed during carotid ultrasonography, but its association with aortic stiffness, a well-defined cardiovascular risk factor, has not been clarified. This study examines the relationship between CCA and aortic stiffness. CCA pressure-strain elastic modulus (Ep) and aortic pulse wave velocity (APWV) were evaluated in 110 healthy volunteers (age 56.2 ± 14.6 y) by B-mode and Doppler ultrasonography. CCA Ep increased linearly with age and was higher in men than in women (model r2 = 0.50, p < 0.001). APWV increased quadratically with age (model r2 = 0.54, p < 0.001), similarly for women and men. Both CCA Ep and APWV were linearly associated with systolic blood pressure (BP) (r = 0.53 and 0.46, respectively) but not with diastolic BP. A linear relationship was found between CCA Ep and APWV (APWV = 194.7 + 5.67 x Ep [model r2 = 0.42, p < 0.001]). CCA Ep was associated with APWV (p < 0.001) independent of age, gender, and BP (model r2 = 0.62, p < 0.001), and the most parsimonious model to explain APWV included CCA Ep and age (APWV = 601.73 - 15.64 x age + 0.223 x age2 + 2.69 x Ep [model r2 = 0.60, p < 0.001]). Thus, CCA Ep is moderately associated with APWV. CCA stiffness as assessed by B-mode may be useful as a surrogate for aortic stiffness.

Original languageEnglish (US)
Pages (from-to)181-188
Number of pages8
JournalUltrasound in Medicine and Biology
Volume25
Issue number2
DOIs
StatePublished - Feb 1 1999
Externally publishedYes

Fingerprint

Pulse Wave Analysis
Vascular Stiffness
Elastic Modulus
arteries
Carotid Arteries
stiffness
modulus of elasticity
Pressure
pulses
blood pressure
Blood Pressure
diastolic pressure
systolic pressure
Doppler Ultrasonography
Ultrasonography
Healthy Volunteers
Arterial Pressure

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics

Cite this

Carotid arterial stiffness as a surrogate for aortic stiffness : Relationship between carotid artery pressure-strain elastic modulus and aortic pulse wave velocity. / Nagai, Yoji; Fleg, Jerome L.; Kemper, Mary K.; Rywik, Tomasz M.; Earley, Christopher J.; Metter, E.

In: Ultrasound in Medicine and Biology, Vol. 25, No. 2, 01.02.1999, p. 181-188.

Research output: Contribution to journalArticle

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