Carotid ultrasonography for detection of vascular abnormalities in hypertensive children

Jonathan M. Sorof, Andrei Alexandrov, Zsolt Garami, Jennifer L. Turner, Robert E. Grafe, Dejian Lai, Ronald J. Portman

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

To determine whether hypertension and overweight status are associated with increased carotid intimal-medial thickness (cIMT) in children, vascular ultrasonography was performed in newly diagnosed hypertensive patients (n=53) and normotensive controls (n=33). Hypertensive subjects were identified either by referral or by systematic school-based hypertension screening. Hypertension was defined as blood pressure above the 95th percentile based on current Task Force criteria, and overweight was defined as body mass index (BMI) >25 kg/m2. cIMT was assessed by high-resolution vascular ultrasonography of the distal common carotid artery. Hypertensive subjects had a higher cIMT than normotensive subjects (0.62 vs. 0.53 mm, P<0.00001). This difference remained significant after controlling for the effects of gender, race, age, height, weight, and BMI. Similarly, overweight subjects had a higher cIMT than normal-weight subjects (0.63 vs. 0.54 mm, P<0.0001). Subjects with both systolic and diastolic hypertension had higher cIMT than those with isolated systolic hypertension (0.67 vs. 0.60, P<0.05). cIMT showed significant positive pairwise correlation with age, height, weight, BMI, and systolic blood pressure. Among all clinical variables analyzed, cIMT was most strongly correlated with BMI (r=0.53, P<0.001). These results provide further evidence that vasculopathy occurs in association with known cardiovascular risk factors such as hypertension and obesity during childhood.

Original languageEnglish (US)
Pages (from-to)1020-1024
Number of pages5
JournalPediatric Nephrology
Volume18
Issue number10
DOIs
StatePublished - Oct 1 2003
Externally publishedYes

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Tunica Intima
Blood Vessels
Ultrasonography
Hypertension
Body Mass Index
Blood Pressure
Weights and Measures
Pediatric Obesity
Common Carotid Artery
Advisory Committees
Referral and Consultation

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Sorof, J. M., Alexandrov, A., Garami, Z., Turner, J. L., Grafe, R. E., Lai, D., & Portman, R. J. (2003). Carotid ultrasonography for detection of vascular abnormalities in hypertensive children. Pediatric Nephrology, 18(10), 1020-1024. https://doi.org/10.1007/s00467-003-1187-0

Carotid ultrasonography for detection of vascular abnormalities in hypertensive children. / Sorof, Jonathan M.; Alexandrov, Andrei; Garami, Zsolt; Turner, Jennifer L.; Grafe, Robert E.; Lai, Dejian; Portman, Ronald J.

In: Pediatric Nephrology, Vol. 18, No. 10, 01.10.2003, p. 1020-1024.

Research output: Contribution to journalArticle

Sorof, JM, Alexandrov, A, Garami, Z, Turner, JL, Grafe, RE, Lai, D & Portman, RJ 2003, 'Carotid ultrasonography for detection of vascular abnormalities in hypertensive children', Pediatric Nephrology, vol. 18, no. 10, pp. 1020-1024. https://doi.org/10.1007/s00467-003-1187-0
Sorof, Jonathan M. ; Alexandrov, Andrei ; Garami, Zsolt ; Turner, Jennifer L. ; Grafe, Robert E. ; Lai, Dejian ; Portman, Ronald J. / Carotid ultrasonography for detection of vascular abnormalities in hypertensive children. In: Pediatric Nephrology. 2003 ; Vol. 18, No. 10. pp. 1020-1024.
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