Case report

Interaction of rifampin and nortriptyline

Timothy Self, Cheryl R. Corley, Said Nabhan, Thomas Abell

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Rifampin is well documented to cause numerous clinically significant drug interactions because of its induction of the hepatic cytochrome P450 system. The metabolism of nortriptyline and other tricyclic antidepressants is induced and inhibited by this enzyme system. To the authors' knowledge, this is only the second case report in the literature regarding a possible interaction between rifampin and a tricyclic antidepressant. Nortriptyline serum concentrations were not detectable while rifampin was given concurrently. Two weeks after discontinuation of rifampin, nortriptyline concentrations increased dramatically. Further study of this possible interaction is warranted.

Original languageEnglish (US)
Pages (from-to)80-81
Number of pages2
JournalAmerican Journal of the Medical Sciences
Volume311
Issue number2
DOIs
StatePublished - Jan 1 1996

Fingerprint

Nortriptyline
Rifampin
Tricyclic Antidepressive Agents
Drug Interactions
Cytochrome P-450 Enzyme System
Liver
Enzymes
Serum

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Case report : Interaction of rifampin and nortriptyline. / Self, Timothy; Corley, Cheryl R.; Nabhan, Said; Abell, Thomas.

In: American Journal of the Medical Sciences, Vol. 311, No. 2, 01.01.1996, p. 80-81.

Research output: Contribution to journalArticle

Self, Timothy ; Corley, Cheryl R. ; Nabhan, Said ; Abell, Thomas. / Case report : Interaction of rifampin and nortriptyline. In: American Journal of the Medical Sciences. 1996 ; Vol. 311, No. 2. pp. 80-81.
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