Case report

Molecular genetic analysis of a primitive neuroectodermal tumor arising after intracranial radiation and chemotherapy for leukemia

Mahlon Johnson, Paul L. Moots, Zhengping Zhuang, Robert J. Weil

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Primitive neuroectodermal tumors are aggressive tumors of the central nervous system (CNS), yet their etiology remains unclear. We report a case of a primitive neuroectodermal tumor (PNET) arising in the cerebellum and pons 7 yr after intracranial radiation and chemotherapy for leukemia involving the CNS. This case suggests a possible link between radiation, chemotherapy, and the formation of these tumors, with a potential new pathogenetic role for somatic inactivation of the protooncogene RET.

Original languageEnglish (US)
Pages (from-to)295-302
Number of pages8
JournalAnnals of Clinical and Laboratory Science
Volume39
Issue number3
StatePublished - Jun 1 2009
Externally publishedYes

Fingerprint

Primitive Neuroectodermal Tumors
Chemotherapy
Tumors
Molecular Biology
Leukemia
Radiation
Drug Therapy
Central Nervous System Neoplasms
Pons
Neurology
Cerebellum
Central Nervous System
Neoplasms

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Microbiology
  • Pathology and Forensic Medicine
  • Immunology
  • Hematology
  • Molecular Biology
  • Clinical Biochemistry
  • Medical Laboratory Technology

Cite this

Case report : Molecular genetic analysis of a primitive neuroectodermal tumor arising after intracranial radiation and chemotherapy for leukemia. / Johnson, Mahlon; Moots, Paul L.; Zhuang, Zhengping; Weil, Robert J.

In: Annals of Clinical and Laboratory Science, Vol. 39, No. 3, 01.06.2009, p. 295-302.

Research output: Contribution to journalArticle

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