Case report

Severe hypertension induced by naloxone

E. R. Levin, Burt Sharp, J. I.M. Drayer, M. A. Weber

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

To evaluate the role of endogenous opioid peptides in regulating the blood pressure of hypertensive individuals, we administered the opiate antagonist, naloxone. One individual developed a severe hypertensive response, mean arterial pressure rising from a baseline of 107 mmHg to 147 mmHg 145 min after naloxone injection and infusion. After stopping naloxone, his blood pressure rapidly returned to baseline. Re-challenge with naloxone and clonidine resulted in a modest reduction of blood pressure in contrast to the profound hypotension induced by clonidine alone during a third session. Thus, endogenous opioids appear to regulate blood pressure in some hypertensive patients and opiate antagonists must be administered with caution to these individuals.

Original languageEnglish (US)
Pages (from-to)70-72
Number of pages3
JournalAmerican Journal of the Medical Sciences
Volume290
Issue number2
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Fingerprint

Naloxone
Opiate Alkaloids
Blood Pressure
Hypertension
Clonidine
Controlled Hypotension
Opioid Peptides
Opioid Analgesics
Arterial Pressure
Injections

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Case report : Severe hypertension induced by naloxone. / Levin, E. R.; Sharp, Burt; Drayer, J. I.M.; Weber, M. A.

In: American Journal of the Medical Sciences, Vol. 290, No. 2, 01.01.1985, p. 70-72.

Research output: Contribution to journalArticle

Levin, E. R. ; Sharp, Burt ; Drayer, J. I.M. ; Weber, M. A. / Case report : Severe hypertension induced by naloxone. In: American Journal of the Medical Sciences. 1985 ; Vol. 290, No. 2. pp. 70-72.
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