CBF changes during brain activation

fMRI vs. PET

Ching Mei Feng, Shalini Narayana, Jack L. Lancaster, Paul A. Jerabek, Thomas L. Arnow, Fang Zhu, Li Hai Tan, Peter T. Fox, Jia Hong Gao

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

The changes in regional cerebral blood flow (rCBF) associated with the changes in neuronal activity are routinely measured both by positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) techniques. However, direct comparison has not been performed to determine similarities and differences of PET and fMRI techniques in determining the rCBF response to brain activation. In the present study, a quantitative comparison of the functional rCBF maps obtained by PET and fMRI are made by performing an activation study in a single group of subjects under precisely controlled conditions and using identical visual stimuli. Twelve healthy volunteers participated in the activation study using the visual checkerboard stimulation with flip frequency at 8 Hz. By selecting the conjunctive pixels which activated on both PET and fMRI maps, the change in rCBF measured by fMRI was 36.95 ± 2.54%, whereas the value measured by PET was 38.79 ± 2.63%. Our results have demonstrated that there is no statistically significant difference (P = 0.22) in the measurements of rCBF change between MRI and PET methods.

Original languageEnglish (US)
Pages (from-to)443-446
Number of pages4
JournalNeuroImage
Volume22
Issue number1
DOIs
StatePublished - May 1 2004

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Cerebrovascular Circulation
Positron-Emission Tomography
Regional Blood Flow
Magnetic Resonance Imaging
Brain
Photic Stimulation
Healthy Volunteers

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

Cite this

Feng, C. M., Narayana, S., Lancaster, J. L., Jerabek, P. A., Arnow, T. L., Zhu, F., ... Gao, J. H. (2004). CBF changes during brain activation: fMRI vs. PET. NeuroImage, 22(1), 443-446. https://doi.org/10.1016/j.neuroimage.2004.01.017

CBF changes during brain activation : fMRI vs. PET. / Feng, Ching Mei; Narayana, Shalini; Lancaster, Jack L.; Jerabek, Paul A.; Arnow, Thomas L.; Zhu, Fang; Tan, Li Hai; Fox, Peter T.; Gao, Jia Hong.

In: NeuroImage, Vol. 22, No. 1, 01.05.2004, p. 443-446.

Research output: Contribution to journalArticle

Feng, CM, Narayana, S, Lancaster, JL, Jerabek, PA, Arnow, TL, Zhu, F, Tan, LH, Fox, PT & Gao, JH 2004, 'CBF changes during brain activation: fMRI vs. PET', NeuroImage, vol. 22, no. 1, pp. 443-446. https://doi.org/10.1016/j.neuroimage.2004.01.017
Feng CM, Narayana S, Lancaster JL, Jerabek PA, Arnow TL, Zhu F et al. CBF changes during brain activation: fMRI vs. PET. NeuroImage. 2004 May 1;22(1):443-446. https://doi.org/10.1016/j.neuroimage.2004.01.017
Feng, Ching Mei ; Narayana, Shalini ; Lancaster, Jack L. ; Jerabek, Paul A. ; Arnow, Thomas L. ; Zhu, Fang ; Tan, Li Hai ; Fox, Peter T. ; Gao, Jia Hong. / CBF changes during brain activation : fMRI vs. PET. In: NeuroImage. 2004 ; Vol. 22, No. 1. pp. 443-446.
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