CD24 and siglec-10 selectively repress tissue damage - Induced immune responses

Guoyun Chen, Jie Tang, Pan Zheng, Yang Liu

Research output: Contribution to journalArticle

388 Citations (Scopus)

Abstract

Patten recognition receptors, which recognize pathogens or components of injured cells (danger), trigger activation of the innate immune system. Whether and how the host distinguishes between danger- versus pathogen-associated molecular patterns remains unresolved. We report that CD24-deficient mice exhibit increased susceptibility to danger- but not pathogen-associated molecular patterns. CD24 associates with high mobility group box 1, heat shock protein 70, and heat shock protein 90; negatively regulates their stimulatory activity; and inhibits nuclear factor κB (NF-κB) activation. This occurs at least in part through CD24 association with Siglec-10 in humans or Siglec-G in mice. Our results reveal that the CD24-Siglec G pathway protects the host against a lethal response to pathological cell death and discriminates danger- versus pathogen-associated molecular patterns.

Original languageEnglish (US)
Pages (from-to)1722-1725
Number of pages4
JournalScience
Volume323
Issue number5922
DOIs
StatePublished - Mar 27 2009
Externally publishedYes

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Sialic Acid Binding Immunoglobulin-like Lectins
HSP90 Heat-Shock Proteins
HSP70 Heat-Shock Proteins
Cellular Structures
Immune System
Cell Death
Pathogen-Associated Molecular Pattern Molecules

All Science Journal Classification (ASJC) codes

  • General

Cite this

CD24 and siglec-10 selectively repress tissue damage - Induced immune responses. / Chen, Guoyun; Tang, Jie; Zheng, Pan; Liu, Yang.

In: Science, Vol. 323, No. 5922, 27.03.2009, p. 1722-1725.

Research output: Contribution to journalArticle

Chen, Guoyun ; Tang, Jie ; Zheng, Pan ; Liu, Yang. / CD24 and siglec-10 selectively repress tissue damage - Induced immune responses. In: Science. 2009 ; Vol. 323, No. 5922. pp. 1722-1725.
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