CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection

Dongling Li, Linghua Zheng, Lei Jin, Yuesu Zhou, Haiying Li, Junliang Fu, Ming Shi, Peishuang Du, Lizhong Wang, Hao Wu, Guoyun Chen, Pan Zheng, Yang Liu, Fu Sheng Wang, Shengdian Wang

Research output: Contribution to journalArticle

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Abstract

T-cell immunity to hepatitis B virus (HBV) is involved in both viral clearance and the pathogenesis of cirrhosis and hepatocellular carcinoma following chronic HBV infection. It is therefore of great interest to analyze whether genetic polymorphism of genes involved in the immune response may determine the outcomes of chronic HBV infection. Here we report that CD24 polymorphisms affect the risk and progression of chronic HBV infection. Thus the CD24 P170T allele, which is expressed at a higher level, is associated with an increased risk of chronic HBV infection. Among the chronic HBV patients this allele shows recessive association with more rapid progression to liver cirrhosis and hepatocellular carcinoma in comparison to the P170 C allele. In contrast, a dinucleotide deletion at position 1527-1528 (P1527del), which reduces CD24 expression, is associated with a significantly reduced risk of chronic HBV infection. To confirm the role for CD24 in liver carcinogenesis, we compared the size of liver tumor developed in CD24-/- and CD24+/- HBV transgenic mice. Our data demonstrate that targeted mutation of CD24 drastically reduced the sizes of spontaneous liver cancer in the HBV transgenic mice. Conclusion: These data demonstrate that genetic variation of CD24 may be an important determinant for the outcome of chronic HBV infection.

Original languageEnglish (US)
Pages (from-to)735-742
Number of pages8
JournalHepatology
Volume50
Issue number3
DOIs
StatePublished - Nov 27 2009

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Chronic Hepatitis B
Virus Diseases
Hepatitis B virus
Alleles
Transgenic Mice
Hepatocellular Carcinoma
Liver
Genetic Polymorphisms
Liver Neoplasms
Liver Cirrhosis
Immunity
Carcinogenesis
Fibrosis
T-Lymphocytes
Mutation

All Science Journal Classification (ASJC) codes

  • Hepatology

Cite this

Li, D., Zheng, L., Jin, L., Zhou, Y., Li, H., Fu, J., ... Wang, S. (2009). CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection. Hepatology, 50(3), 735-742. https://doi.org/10.1002/hep.23047

CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection. / Li, Dongling; Zheng, Linghua; Jin, Lei; Zhou, Yuesu; Li, Haiying; Fu, Junliang; Shi, Ming; Du, Peishuang; Wang, Lizhong; Wu, Hao; Chen, Guoyun; Zheng, Pan; Liu, Yang; Wang, Fu Sheng; Wang, Shengdian.

In: Hepatology, Vol. 50, No. 3, 27.11.2009, p. 735-742.

Research output: Contribution to journalArticle

Li, D, Zheng, L, Jin, L, Zhou, Y, Li, H, Fu, J, Shi, M, Du, P, Wang, L, Wu, H, Chen, G, Zheng, P, Liu, Y, Wang, FS & Wang, S 2009, 'CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection', Hepatology, vol. 50, no. 3, pp. 735-742. https://doi.org/10.1002/hep.23047
Li, Dongling ; Zheng, Linghua ; Jin, Lei ; Zhou, Yuesu ; Li, Haiying ; Fu, Junliang ; Shi, Ming ; Du, Peishuang ; Wang, Lizhong ; Wu, Hao ; Chen, Guoyun ; Zheng, Pan ; Liu, Yang ; Wang, Fu Sheng ; Wang, Shengdian. / CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection. In: Hepatology. 2009 ; Vol. 50, No. 3. pp. 735-742.
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