CD4 count is predictive of outcome in HIV-positive patients undergoing abdominal operations

Jeremiah Deneve, Jessica G. Shantha, Andrew J. Page, Amy D. Wyrzykowski, Grace S. Rozycki, David V. Feliciano

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: The impact of immune status and surgical outcome in patients with HIV and acquired immunodeficiency syndrome (AIDS) remains unknown. Methods Clinical variables of HIV/AIDS patients undergoing abdominal surgery were examined for their impact on outcome. Results Major abdominal procedures were performed in 77 patients with a diagnosis of HIV/AIDS (55 males, mean age 41.1 years, mean CD4 count 210 mg/dL). A majority of operations (53%) were performed on an urgent basis. Patients undergoing urgent procedures had lower CD4 counts (129 ± 121 vs 303 ± 324, P = .002). The mean CD4 count was lower for patients with complications (146 ± 156 vs 288 ± 319, P = .013) and for those who died (112 ± 113 vs 251 ± 283, P = .026). On multivariate analysis, CD4 count was independently associated with an increased risk for complication, and urgent operation was associated with an increased risk for mortality. Conclusion Patients with HIV/AIDS who had lower CD4 counts were more likely to require an urgent operation and experience a complication with increased mortality.

Original languageEnglish (US)
Pages (from-to)694-700
Number of pages7
JournalAmerican Journal of Surgery
Volume200
Issue number6
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

Fingerprint

CD4 Lymphocyte Count
HIV
Acquired Immunodeficiency Syndrome
Mortality
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

CD4 count is predictive of outcome in HIV-positive patients undergoing abdominal operations. / Deneve, Jeremiah; Shantha, Jessica G.; Page, Andrew J.; Wyrzykowski, Amy D.; Rozycki, Grace S.; Feliciano, David V.

In: American Journal of Surgery, Vol. 200, No. 6, 01.12.2010, p. 694-700.

Research output: Contribution to journalArticle

Deneve, Jeremiah ; Shantha, Jessica G. ; Page, Andrew J. ; Wyrzykowski, Amy D. ; Rozycki, Grace S. ; Feliciano, David V. / CD4 count is predictive of outcome in HIV-positive patients undergoing abdominal operations. In: American Journal of Surgery. 2010 ; Vol. 200, No. 6. pp. 694-700.
@article{4ee75558f89d472ea6497088fcba6704,
title = "CD4 count is predictive of outcome in HIV-positive patients undergoing abdominal operations",
abstract = "Background: The impact of immune status and surgical outcome in patients with HIV and acquired immunodeficiency syndrome (AIDS) remains unknown. Methods Clinical variables of HIV/AIDS patients undergoing abdominal surgery were examined for their impact on outcome. Results Major abdominal procedures were performed in 77 patients with a diagnosis of HIV/AIDS (55 males, mean age 41.1 years, mean CD4 count 210 mg/dL). A majority of operations (53{\%}) were performed on an urgent basis. Patients undergoing urgent procedures had lower CD4 counts (129 ± 121 vs 303 ± 324, P = .002). The mean CD4 count was lower for patients with complications (146 ± 156 vs 288 ± 319, P = .013) and for those who died (112 ± 113 vs 251 ± 283, P = .026). On multivariate analysis, CD4 count was independently associated with an increased risk for complication, and urgent operation was associated with an increased risk for mortality. Conclusion Patients with HIV/AIDS who had lower CD4 counts were more likely to require an urgent operation and experience a complication with increased mortality.",
author = "Jeremiah Deneve and Shantha, {Jessica G.} and Page, {Andrew J.} and Wyrzykowski, {Amy D.} and Rozycki, {Grace S.} and Feliciano, {David V.}",
year = "2010",
month = "12",
day = "1",
doi = "10.1016/j.amjsurg.2010.07.030",
language = "English (US)",
volume = "200",
pages = "694--700",
journal = "American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - CD4 count is predictive of outcome in HIV-positive patients undergoing abdominal operations

AU - Deneve, Jeremiah

AU - Shantha, Jessica G.

AU - Page, Andrew J.

AU - Wyrzykowski, Amy D.

AU - Rozycki, Grace S.

AU - Feliciano, David V.

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Background: The impact of immune status and surgical outcome in patients with HIV and acquired immunodeficiency syndrome (AIDS) remains unknown. Methods Clinical variables of HIV/AIDS patients undergoing abdominal surgery were examined for their impact on outcome. Results Major abdominal procedures were performed in 77 patients with a diagnosis of HIV/AIDS (55 males, mean age 41.1 years, mean CD4 count 210 mg/dL). A majority of operations (53%) were performed on an urgent basis. Patients undergoing urgent procedures had lower CD4 counts (129 ± 121 vs 303 ± 324, P = .002). The mean CD4 count was lower for patients with complications (146 ± 156 vs 288 ± 319, P = .013) and for those who died (112 ± 113 vs 251 ± 283, P = .026). On multivariate analysis, CD4 count was independently associated with an increased risk for complication, and urgent operation was associated with an increased risk for mortality. Conclusion Patients with HIV/AIDS who had lower CD4 counts were more likely to require an urgent operation and experience a complication with increased mortality.

AB - Background: The impact of immune status and surgical outcome in patients with HIV and acquired immunodeficiency syndrome (AIDS) remains unknown. Methods Clinical variables of HIV/AIDS patients undergoing abdominal surgery were examined for their impact on outcome. Results Major abdominal procedures were performed in 77 patients with a diagnosis of HIV/AIDS (55 males, mean age 41.1 years, mean CD4 count 210 mg/dL). A majority of operations (53%) were performed on an urgent basis. Patients undergoing urgent procedures had lower CD4 counts (129 ± 121 vs 303 ± 324, P = .002). The mean CD4 count was lower for patients with complications (146 ± 156 vs 288 ± 319, P = .013) and for those who died (112 ± 113 vs 251 ± 283, P = .026). On multivariate analysis, CD4 count was independently associated with an increased risk for complication, and urgent operation was associated with an increased risk for mortality. Conclusion Patients with HIV/AIDS who had lower CD4 counts were more likely to require an urgent operation and experience a complication with increased mortality.

UR - http://www.scopus.com/inward/record.url?scp=78650221752&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650221752&partnerID=8YFLogxK

U2 - 10.1016/j.amjsurg.2010.07.030

DO - 10.1016/j.amjsurg.2010.07.030

M3 - Article

VL - 200

SP - 694

EP - 700

JO - American Journal of Surgery

JF - American Journal of Surgery

SN - 0002-9610

IS - 6

ER -